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OTUD1 deubiquitinates AIFM1 on K244. 1 / 1

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"As an example of AIF posttranslational modifications, it was reported that the X-linked inhibitor of apoptosis (XIAP) ubiquitinates AIF at K255 and consequently regulates AIF pro-apoptotic features, rather than its proteasomal degradation or NADH oxidoreductase properties.78 79 On the other hand, OTU deubiquitinase 1 (OTUD1) directly deubiquitinates AIF at K244 and alters AIF binding to CHCHD4, resulting in impaired OXPHOS and swollen mitochondria lacking intact cristae."

35994922

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OTUD1 deubiquitinates AIFM1 on K244. 1 / 1

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