IndraLab
Statements
OTUD1 activates Polyubiquitin. 1 / 1
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"In short, OTUD1 prefers abolishing proteosome-mediated NRF2 degradation rather than modulating NRF2 function through removing K63 polyubiquitin scaffold.Due to its robust cytoprotective role in preventing oxidative stress and inflammation, NRF2 activation is considered a promising therapeutic strategy for numerous diseases characterized by oxidative stress [40]."