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OTUD1 leads to the dephosphorylation of MAP3K5. 2 / 2

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"Mechanically, Otud1 directly interacts with Pgam5 and Ask1 to inhibit Pgam5 ubiquitination degradation and subsequently elevate Ask1 phosphorylation."

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"In addition, loss of OTUD1 reduced the c-Jun phosphorylation level in SKOV3, OVCAR8 and CAOV3 cells (Supplementary Fig. 2e), implying that OTUD1 probably regulates OSCS by activating the JNK/c-Jun pathway.Moreover, depletion of OTUD1 reduced the ASK1 phosphorylation level in SKOV3 and OVCAR8 cells (Supplementary Fig. 2f)."

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IndraLab

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OTUD1 leads to the dephosphorylation of MAP3K5. 2 / 2

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