IndraLab

Statements

OTUD1 inhibits MAVS. 3 / 3
| 3
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"In the presence of MG132, the ability of OTUD1 to downregulate MAVS (XREF_FIG), or TRAF3 (XREF_FIG), or TRAF6 (XREF_FIG) was largely inhibited."
29734366
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"In addition, RNA viral infection induces OTUD1 expression, which deubiquitinates and stabilizes Smurf1, therefore enhancing Smurf1-mediated MAVS degradation to negatively regulate MAVS function (167)."
35795661
reach
"These data indicate that OTUD1 inhibits the IFNs antiviral response downstream of MAVS and upstream of TBK1."
29734366