IndraLab

Statements

OTUD1 inhibits MAVS. 3 / 3
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reach
"These data indicate that OTUD1 inhibits the IFNs antiviral response downstream of MAVS and upstream of TBK1."
29734366
reach
"In the presence of MG132, the ability of OTUD1 to downregulate MAVS (XREF_FIG), or TRAF3 (XREF_FIG), or TRAF6 (XREF_FIG) was largely inhibited."
29734366
reach
"In addition, RNA viral infection induces OTUD1 expression, which deubiquitinates and stabilizes Smurf1, therefore enhancing Smurf1-mediated MAVS degradation to negatively regulate MAVS function (167)."
35795661