IndraLab

Statements

OTUD1 activates Interferon. 6 / 6
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"Ovarian tumor deubiquitinase 1 (OTUD1) is a critical member of OUT deubiquitinases, which has been identified as a negative regulator in IRF3-mediated interferon signaling in mammals."
40350101
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"OTUD1 could upregulate the interferon (IFN) antiviral pathway and improve the immune ability (Zhang et al., 2020)."
38479099
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"Importantly, otud1 -deficient mice were more resistant against lethal RNA (VSV) and DNA (HSV) virus infection and produced more protective type I IFN and cytokines [ 22 ]."
34016513
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"OTUD1 negatively regulates the canonical NF-kappaB activation, apoptosis, and necroptosis, whereas OTUD1 upregulates the interferon (IFN) antiviral pathway."
35941131
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"Both Smurf1 and the deubiquitinase activity of OTUD1 are required for OTUD1 mediated downregulation of MAVS/TRAF3/TRAF6 and inhibition of interferon antiviral response."
29734366
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"OTUD1 activates IFN antiviral signaling."
35941131