IndraLab

Statements

OTUD1 activates STAT3. 7 / 7
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"These results demonstrate that OTUD1 promotes Ang II-induced cardiac remodeling and dysfunction through activating STAT3."
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"The first study demonstrated that OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes."
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"In addition, OTUD1 and USP15 appear to modulate cardiac myocyte remodeling in the context of heart failure, the former by targeting STAT3 [137,138]."
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"OTUD1 interacts directly with STAT3 and promotes STAT3 activation."
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"Conversely, expression of OTUD1 in cardiomyocytes exacerbated Ang II-induced p-STAT3 (Figure 5F, Figure S5B)."
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"OTUD1 increases Ang II-induced cardiomyocyte myocardial hypertrophy and fibrosis by regulating STAT3."
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"OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes."
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