IndraLab

Statements

OTUD1 binds TP53. 20 / 21
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"However, OTUD1 1-311 and OTUD1 1-185 mutants did not interact with p53 ( Fig. 3 D)."
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"We conducted the same coexpression experiment by performing immunoprecipitation with anti-Myc antibody and immunoblotting with anti-Flag antibody and observed a similar interaction between OTUD1 and p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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sparser
"OTUD1 interacts with p53 and is essential for constant stabilization of p53."
35874839
biogrid
No evidence text available
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sparser
"Thus, the results of the present study highlight a new therapeutic opportunity for preventing some disease such as cancer by targeting the OTUD1-p53 axis."
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trips
"Moreover, we observed that OTUD1 directly interacted with p53."
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sparser
"In addition to these functions, OTUD1 interacts directly with p53 and deubiquitinates p53."
35874820
sparser
"Binding assays showed that deletion of the UIM strengthened the interaction between OTUD1 and p53."
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reach
"DNA damage enhances the interaction between OTUD1 and p53, so OTUD1 primarily plays a role in the G2/M and S checkpoints of the cell cycle [36]."
36613989
sparser
"DNA damage enhances the interaction between OTUD1 and p53, so OTUD1 primarily plays a role in the G2/M and S checkpoints of the cell cycle [ xref ]."
36613989
biogrid
No evidence text available
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reach
"OTUD1 reportedly binds and stabilizes p53, a crucial tumor suppressor, in a DUB-activity-dependent manner [21]."
36829909
reach
"These results suggest a specific interaction between OTUD1 and p53 in cells."
28216291
reach
"To determine whether the interaction between OTUD1 and p53 was domain specific, we generated various deletion mutants of OTUD1 ( Fig. 3 C)."
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reach
"Binding assays showed that deletion of the UIM strengthened the interaction between OTUD1 and p53."
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sparser
"OTUD1 reportedly binds and stabilizes p53, a crucial tumor suppressor, in a DUB-activity-dependent manner [ xref ]."
36829909
sparser
"To examine whether OTUD1 physically interacted with p53, we performed a coimmunoprecipitation assay by using U2OS cells."
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sparser
"These results suggest a specific interaction between OTUD1 and p53 in cells."
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sparser
"To determine whether the interaction between OTUD1 and p53 was domain specific, we generated various deletion mutants of OTUD1 ( Fig. 3 C)."
28216291
sparser
"Our results showed that FL OTUD1 (1-481) significantly interacted with p53."
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