IndraLab

Statements

OTUD1 binds PGAM5. 9 / 9
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"The binding of Pgam5 and Otud1 was validated by both exogenous and endogenous immunoprecipitation."
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"The binding of Pgam5 and Otud1 was validated by both exogenous and endogenous immunoprecipitation."
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"This upregulated OTUD1 then interacts with and deubiquitinates PGAM5, promoting ASK1 phosphorylation and the activation of the p38/JNK MAPK signaling pathway."
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No evidence text available
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"Therefore, our findings showed that OTUD1 interacts with PGAM5 and promotes its ubiquitination and degradation."
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"OTUD1 binds to and deubiquitinates PGAM5."
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"OTUD1 binds to and deubiquitinates PGAM5."
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"Conclusion : Our findings confirm that targeting the OTUD1-PGAM5 axis holds significant potential as a therapeutic approach for heart failure associated with pathological hypertrophy."
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"The initial confirmation of the interaction between OTUD1 and PGAM5 was conducted in 293T cells (Figure xref C-D)."
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