IndraLab

Statements

OTUD1 inhibits KLF4. 3 / 3
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"Another study identified that the deubiquitinase OTUD1 suppressed tumor progression by stabilizing KLF4 in NSCLC cells [148] ."
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
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"OTUD1 upregulation suppressed cell viability and invasion and migration via mediating stabilization of KLF4, while silencing of OTUD1 showed the opposite effect [148] ."
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