IndraLab

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OTUD1 leads to the deubiquitination of SMURF1. 1 / 1
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"Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination dependent manner, ultimately inhibiting IFN-I production."