IndraLab

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OTUD1 deubiquitinates SMURF1. 4 / 5
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"During RNA virus infection, OTUD1 is induced through the NF-κB pathway, and OTUD1 deubiquitinates Smurf1 to up-regulate the protein level of Smurf1 in cells."
36505476
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"Furthermore, OTUD1 induced upregulation of the E3 ubiquitin ligase Smurf1 by deubiquitinating Smurf1, and Smurf1 degraded MAVS in MDBK cells in a ubiquitination dependent manner, ultimately inhibiting IFN-I production."
33361422
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"In addition, RNA viral infection induces OTUD1 expression, which deubiquitinates and stabilizes Smurf1, therefore enhancing Smurf1-mediated MAVS degradation to negatively regulate MAVS function (167)."
35795661
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"The specific mechanism is: DDIT3 expression induces the production of OTUD1, which promotes the upregulation of Smurf1 expression by deubiquitinating Smurf1, and Smurf1 as E3 will degrade MAVS in a ubiquitin-dependent manner to inhibit IFN-I signaling (194)."
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