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OTUD1 activates IREB2. 2 / 2

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"OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transport through deubiquitination and stabilization of IREB2, leading to increased ROS production and ferroptosis."

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"For example, OTUD1 has been shown to enhances iron transport and potentiate antitumor immunity in colon cancer by targeting/regulating iron-responsive element-binding protein 2 33."

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OTUD1 activates IREB2. 2 / 2

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