IndraLab

Statements

OTUD1 is methylated. 7 / 7
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"meRIP-qPCR of OTUD1 methylation levels in human BEAS-2B cells treated with 10% CSE demonstrated that the m6A methylation level was significantly elevated in the 10% CSE-treated cells compared with that in the control group ( xref ), which indicated that 10% CSE stimulation could inhibit OTUD1 expression by increasing m6A."
40417884
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"CSE stimulation promotes OTUD1 methylation by increasing METTL3 activity, which in turn inhibits OTUD1 gene expression."
40417884
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"Related literature has indicated that methyltransferase-like 3 (METTL3) can promote m6A methylation ( xref ) and COPD progression, whereas METTL3 silencing can reduce OTUD1 mRNA m6A methylation, thereby enhancing OTUD1 protein expression ( xref )."
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"CSE (10%) was shown to inhibit OTUD1 expression by upregulating METTL3, which may enhance METTL3-mediated methylation and promote YTHDF2 recognition of OTUD1 methylation."
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"Using MethPrimer, we identified methylation sites and designed primers to evaluate TFAP2C and OTUD1 methylation levels in radiosensitive and radioresistant cell lines (Supplementary Fig. xref )."
40664662
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"Therefore, by knocking down METTL3, it was further verified that 10% CSE stimulation may promote OTUD1 methylation by increasing METTL3 activity, which in turn suppresses OTUD1 gene expression."
40417884
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"The results showed that METTL3 levels were increased following 10% CSE stimulation, leading to elevated m6A methylation of OTUD1 and reduced OTUD1 expression."
40417884