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OTUD1 activates FGL1. 3 / 3
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"For example, OTUD1 can enhance the stability of fibrinogen-like protein 1 in liver microenvironment and thus regulate tumor progression via tumor associated macrophages-OTUD1- fibrinogen-like protein 1 axis (Li et al., 2023a); moreover, OTUD1 can serve a negative prognostic factor for hepatocellular carcinoma (Wu et al., 2019)."
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"However, knockdown of either OTUD1 or FGL1 in MC38 cells reduced hepatic metastases, which could be rescued by overexpressing rFGL1, indicating the critical role of FGL1 in TNFα-mediated progression of metastatic tumors (Fig. 6A, B)."
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"Mechanistically, tumor-associated macrophages (TAMs) activate NF-kB by secreting TNFalpha/IL-1beta in the liver microenvironment and transcriptionally upregulate OTU deubiquitinase 1 (OTUD1) expression, which enhances FGL1 stability via deubiquitination."
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