IndraLab

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OTUD1 inhibits RLR. 3 / 3
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"Finally, the deubiquitinase OTUD1 potently inhibits RLR pathway by utilizing Smurf1-MAVS/TRAF3/TRAF6 signaling at the early stage of viral infection."
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"OTUD1 then removes the K63-linked ubiquitin chain from K98 of IRF3 and attenuates the RIG-I-like receptors (RLRs)-mediated IFN production pathway (Figure 4A)."
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"Our study clearly demonstrates that the deubiquitinase OTUD1 negatively regulates RLR signaling."
29734366