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OTUD1 inhibits cell cycle. 2 / 2

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"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability (Figure 2C)."

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"These results suggest that OTUD1 inhibits cell proliferation by regulating cell cycle and apoptosis.p53 is a master transcription factor that performs critical regulatory functions in cells."

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IndraLab

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OTUD1 inhibits cell cycle. 2 / 2

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