IndraLab

Statements

OTUD1 inhibits cell growth. 5 / 5
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
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"A CCK‐8 assay was performed to prove that overexpression of OTUD1 significantly suppressed cell growth (p < 0.01, Figure 2b)."
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"Moreover, we observed that OTUD1 overexpression induced p53-dependent apoptosis and dramatically inhibited cell growth."
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"In this process, OTUD1 could remove the K63 linkage ubiquitination of YAP and negatively regulate transcriptional activity and cell growth."
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"As expected, OTUD1 oe suppressed myeloma cell growth while introduction of sh OTUD1 promoted proliferation (Fig. 2f, g)."
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