IndraLab

Statements


OTUD1 activates BCL2L11. 2 / 2
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"Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation."

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"In addition, melatonin-induced activation of Sp1 was found to be involved in OTUD1 upregulation at the transcriptional level, and pharmacological inhibition and genetic ablation of Sp1 (siRNA) interrupted melatonin-induced OTUD1-mediated Bim upregulation."