IndraLab

Statements

OTUD1 increases the amount of NFE2L2. 3 / 3
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"The slowed degradation of Nrf2 and YAP with the high expression of USP17 and OTUD1 was detected in the chemoresistant PDAC cell line, and the knockdown of OTUD1 reduced the levels of Nrf2 and YAP, and cell growth."
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"As expected, OTUD1 dose-dependently increased the protein level of NRF2 (Fig. 4B)."
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"Our results showed that overexpression of OTUD1-WT strongly increased NRF2 protein levels, while overexpression of either the inactive mutant C320S (M1) or ETGE deletion mutant (M2) only slightly increased NRF2 protein levels."
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