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OTUD1 binds STAT3. 12 / 12
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"These in vitro studies show that OTUD1 interacts with STAT3 and regulates Tyr-705 phosphorylation and nuclear translocation to module expression of cardiac remodeling genes."
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"These results indicate that STAT3 binds to OTUD1 directly via STAT3 SH2 domain."
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"After identifying STAT3-OTUD1 interaction site, we mutated active sites on OTUD1 (cysteine at position 320 to serine) (Figure xref E)."
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"Mechanistically, we showed that OTUD1 binds to STAT3 and causes deubiquitination of STAT3."
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"This study further elucidated that OTUD1 bound to the SH2 domain of STAT3 through its cysteine site at position 320, thereby exerting the effect of deubiquitination (Ref. xref )."
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"To confirm this potential interaction between OTUD1 and STAT3, we transfected NVRMs and HEK-293T cells with Flag-tagged OTUD1 and showed that STAT3 interacts with OTUD1 following co-IP assay (Figure 5C-D)."
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"We tested the idea that OTUD1 binding to STAT3 may disrupt STAT3-KPNA3 association, which possibly reduces nuclear translocation."
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"Mechanistically, we showed that OTUD1 binds to STAT3 and causes deubiquitination of STAT3."
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"Our detailed mechanistic studies showed that OTUD1 interacts with signal transducer and activator of transcription 3 (STAT3) and leads to deubiquitination and increased phosphorylation of STAT3."
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"OTUD1 interacts directly with STAT3 and promotes STAT3 activation."
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"Representative MS spectra of STAT3 is shown in Figure xref B. To confirm this potential interaction between OTUD1 and STAT3, we transfected NVRMs and HEK-293T cells with Flag-tagged OTUD1 and showed that STAT3 interacts with OTUD1 following co-IP assay (Figure xref C-D)."
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"We tested the idea that OTUD1 binding to STAT3 may disrupt STAT3-KPNA3 association, which possibly reduces nuclear translocation."
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