IndraLab

Statements

AMPK binds OTUD1. 7 / 7
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"In conclusion, this work identifies a direct regulatory DUB of AMPK and presents a OTUD1-AMPK axis in cardiomyocytes for driving DCM."
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"Our study illustrated a detrimental effect of OTUD1 and identified a cardiomyocyte-specific OTUD1-AMPK axis in mediating DCM, suggesting that targeting OTUD1 represents a potential therapy strategy for DCM."
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"Consequently, our finding reveals an OTUD1-AMPK axis in promoting DCM pathology and provides OTUD1 as a potential therapeutic target against DCM."
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"We then validated the OTUD1-AMPK axis in cultured cardiomyocytes under HG, combining PA stimulation (HG + PA)."
40683882
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"This work extends our understanding of the role of DUBs in regulating AMPK activity and presents an OTUD1-AMPK axis in mediating diabetes-induced cardiomyocyte energy metabolism and DCM."
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"Therefore, the OTUD1-AMPK axis regulates glucose/lipid metabolism and mitochondrial bioactivity in cardiomyocytes, which represents a crucial molecular mechanism in the pathogenesis of DCM."
40683882
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"Thus, in addition to AMPKα2, we wondered whether OTUD1 binds to other AMPK subunits."
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