IndraLab

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OTUD1 deubiquitinates KLF4. 6 / 6
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"As shown in Figure 5e, OTUD1 overexpression notably repressed the polyubiquitination of KLF4 protein (Figure 5e)."
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"These findings suggest that OTUD1 deubiquitinated KLF4, thereby inhibiting KLF4 protein degradation."
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"41 , 48 We confirmed that OTUD1 obviously extended half‐lives of KLF4 and inhibited KLF4 ubiquitination level."
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"The deubiquitinase OTUD1 inhibits progression by deubiquitinating and stabilizing KLF4 in non-small cell lung cancer [10]."
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"OTUD1 was positively correlated with KLF4 and stabilized KLF4 at protein level by deubiquitinating KLF4."
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"OTUD1 stabilizes KLF4 by deubiquitinating KLF4 ."
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