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OTUD1 activates ISO. 4 / 4
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"These findings provided evidence that myeloid OTUD1 mediated ISO‐induced CARD9‐BCL10 interaction, cardiac inflammation, hypertrophy and dysfunction in mice.4 DISCUSSION."
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"In summary, we have demonstrated that the macrophage OTUD1‐CARD9 axis mediates ISO‐induced inflammatory response, subsequently contributing to heart remodelling."
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"Macrophage OTUD1 mediates ISO‐driven inflammatory responses by deubiquitinating CARD9 and increasing the combination of CARD9 and BCL10.The cellular mechanism linking CARD9 to CLRs, specifically through the Dectin‐1 signalling pathway, has been well‐documented in the context of fungal and parasitic infections."
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"Noninvasive echocardiography showed that OTUD1 deficiency significantly inhibited ISO‐induced cardiac dysfunction (Table 3 and Figure S13A)."
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