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OTUD1 deubiquitinates CARD9. 5 / 5
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"OTUD1 interacts with CARD9 through the OTU + UIM domain and deubiquitinates CARD9 [44] (Figure 4C)."
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"26 Here, we found that OTUD1 deubiquitinated CARD9 in ISO‐challenged macrophages and mouse hearts."
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"OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9."
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"Our previous study showed OTUD1 played an essential role in antifungal innate immunity by deubiquitinating Caspase recruitment domain-containing protein 9 (CARD9) and regulating the CARD9 signaling pathway [18]."
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"Mechanistically, we demonstrated that a deubiquitinating enzyme, ovarian tumour deubiquitinase 1 (OTUD1), directly deubiquitinated CARD9 to promote the assembly of the CBM complex and then activate NF‐κB signalling in macrophages."
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