IndraLab

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OTUD1 binds PTEN. 5 / 5
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"Therefore, the OTUD1–PTEN axis suppresses tumor growth and regulates the resistance of ccRCC to tyrosine kinase inhibitors."
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"First, the reciprocal immunoprecipitation assay indicated that endogenous OTUD1 interacts with PTEN in 786-O and ACHN cells (Fig. xref B, C)."
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"Furthermore, OTUD1 interacts with PTEN and regulates its stability."
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"Thus, we identified that the OTUD1-PTEN axis suppresses tumor growth and regulates the resistance of renal cancer to TKIs."
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"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability ( xref C)."
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