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OTUD1 decreases the amount of TFRC. 2 / 2
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"OTU deubiquitinase 1 (OTUD1) acts as a deubiquitinase of iron-responsive element-binding protein 2 (IREB2) and blocks its degradation, thereby promoting CD71 expression and augmenting cellular iron up[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"143 OTUD1 promotes the deubiquitination of IREB2, which inhibits the degradation of IREB2 protein and activates the expression of TFRC, thereby increasing the concentration of iron ions in tumor cells and enhancing the sensitivity to ferroptosis as well as the infiltration of CD8+ T cells, improving antitumor immune response."
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