IndraLab

Statements

OTUD1 inhibits IFNbeta promoter. 3 / 3
| 3
reach
"Results showed that knockdown of OTUD1 significantly enhanced activation of IFNbeta promoter during SeV infection (XREF_SUPPLEMENTARY), and overexpression of OTUD1 inhibited SeV induced activation of IFNbeta promoter (XREF_SUPPLEMENTARY)."
29734366
reach
"To further determine at what level in RLRs mediated antiviral signaling pathway OTUD1 blocked activation of IFNbeta promoter, three expression constructs (RIG-I, MAVS, or TBK1) were overexpressed in cells in the presence or absence of OTUD1."
29734366
reach
"The results showed that OTUD1 overexpression dramatically inhibited IFNbeta promoter activation driven by both RIG-I and MAVS (XREF_FIG), whereas IFNbeta promoter activation by TBK1 (XREF_FIG) was not inhibited by OTUD1 coexpression."
29734366