IndraLab

Statements

Mutated OTUD1 inhibits immune response. 2 / 2
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"Our data demonstrate that OTUD1 is involved in maintaining immune homeostasis and loss-of-function mutations of OTUD1 enhance the immune response and are associated with autoimmunity."
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"Meanwhile, previous studies have demonstrated that Otud1 knockout mice were more susceptible to lipopolysaccharide (LPS)-induced sepsis [11], and loss-of-function mutations of OTUD1 enhanced immune response and were associated with autoimmunity [12], suggesting a potential role for OTUD1 in hepatic inflammation caused by I/R."
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