IndraLab

Statements

OTUD1 inhibits TGFB. 7 / 7
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"OTUD1 causes suppression of TGF-beta downstream signals and EMT."
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"Moreover , OTUD1 suppresses TGF-beta signaling and EMT in MCF10A cells expressing RAS and metastasis of breast cancer cells in mice , respectively , presumably through deubiquitylating SMAD7 thus enabling SMURF2 binding and subsequent TGFR turnover43 ."
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"We next investigated the molecular mechanism by which OTUD1 inhibits TGF-beta and SMAD signaling."
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"Ectopic expression of OTUD1 could suppress TGF-beta signaling in control cells but barely showed effect in SMAD7 deficient cells; also knockdown of OTUD1 could promote TGF-beta signaling in control cells but not in SMAD7 deficient cells, suggesting thatinhibitory SMAD7 might be the major target of OTUD1 in the TGF-beta pathway."
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"For instance, deubiquitination of FOXM1 induces cancer progression and chemoresistance through the DUB UCHL3; OTUD1 reduces the pro-oncogenic TGF-β signaling mediated by SMAD7 to suppress the metastasis in breast cancer [93,94]."
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"In this model, OTUD1 represses breast cancer metastasis by mitigating TGF-β activity and loss of OTUD1 in aggressive forms derives TGF-β signaling and metastasis."
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"It was reported that OTUD1 could specifically inhibit transforming growth factor-beta (TGF-β) signaling in breast cancer metastasis by empowering SMAD7 [11]."
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