IndraLab

Statements

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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
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"OTUD1 overexpression inhibits NSCLC cell proliferation, migration and invasion."
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"Taken together, these results suggested that overexpression OTUD1 notably inhibits NSCLC cell progression including proliferation, migration and invasion."
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"OTUD1 knockdown promotes NSCLC cell proliferation, migration and invasion."
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"Transwell assay demonstrated that silencing OTUD1 significantly accelerated PC9 and A549 cell migration and invasion (p < 0.01, Figure 3c,d)."
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"OTUD1 upregulation suppressed cell viability and invasion and migration via mediating stabilization of KLF4, while silencing of OTUD1 showed the opposite effect [148] ."
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