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OTUD1 activates Neoplasm Metastasis. 2 / 2

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"OTUD1 is a deubiquitinase and among its targets is SMAD7, and OTUD1 deficiency destabilizes SMAD7 and potentiates TGF-beta1-driven metastasis [XREF_BIBR]."

29799477

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reach

"However, knockdown of either OTUD1 or FGL1 in MC38 cells reduced hepatic metastases, which could be rescued by overexpressing rFGL1, indicating the critical role of FGL1 in TNFα-mediated progression of metastatic tumors (Fig. 6A, B)."

37872170

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IndraLab

Statements

OTUD1 activates Neoplasm Metastasis. 2 / 2

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