IndraLab

Statements

USP39 activates cell population proliferation. 10 / 56
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"It was found in our previous study that USP39 knockdown could inhibit the abnormal proliferation of prostate cancer cells by inhibiting the splicing maturation and transcriptional prolongation of EGFR mRNA [16]."
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"Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro."
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"USP39 knockdown inhibited the proliferation and colony formation of A549 and HCC827 cells and decreased tumorigenic potential in nude mice."
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"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
27456357
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"The inducible shRNA mediated downregulation of USP39 expression markedly reduced the proliferation and colony forming ability of MDA-MB-231 cells, while overexpression of USP39 by the inducible system did not promote cancer cell proliferation."
25812575
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"In addition, overexpression of HMGA2 rescued the inhibition of proliferation, invasion and xenograft growth induced by silencing USP39."
33731694
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"Simultaneously, USP39 knockdown inhibited the proliferation of HCC cells transfected with shTRIM26."
33649471
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"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
36707504
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"In conclusion, the present study has revealed that USP39 silencing suppressed CRC cell proliferation via activating the caspase cascade and upregulating the expression of p53."
29556295
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"Furthermore, these results suggested that suppression of USP39 could inhibit cell proliferation and colony formation of HCC cells."
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"USP39 overexpression deprived miR-133a inhibitor mediated suppression of cell proliferation, suggesting that USP39 is involved in miR-133a-mediated biological role in gastric cancer cell HGC-27 (P < 0.0001) (XREF_FIG)."
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"Wang et al. [21] also found that USP39 was highly expressed in breast cancer cells, and down-regulation of USP39 could significantly reduce the proliferation and colony formation of breast cancer cells."
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"Knockdown of USP39 significantly inhibited proliferation of TT cells in vitro."
26303214
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"Knockdown of USP39 significantly decreased cell proliferation and caused cell cycle arrest at G2/M phase."
26303214
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"We further observed that USP39 downregulation inhibits the cell proliferation and migration of A549 and HCC827 cells."
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"USP39 downregulation could inhibit RCC cell proliferation and progression, suggesting that USP39 may prove to be a potential target for inhibiting RCC."
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
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"Furthermore, knockdown of USP39 inhibited VSMC cell proliferation and the expression of cyclin D1 and cyclin-dependent kinase 4, as analyzed via cell counting, MTT assay and western blotting."
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"In addition, it has been reported that overexpression of MGC-803 cells and knockdown of USP39 may inhibit MGC-803 cell proliferation and induce cell cycle arrest."
29805563
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
26959883
USP39 affects apoptotic process
| 42
USP39 inhibits apoptotic process.
| 34
USP39 inhibits apoptotic process. 10 / 37
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"Collectively, our data suggest that knocking down USP39 induces cell cycle arrest at S phase and G2/M phase, and results in apoptosis, and that the mechanism of apoptosis induced by USP39 knockdown may be related to DNA damage."
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"Conversely, overexpression of USP39 attenuates apoptosis in RKO cells."
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"In order to further demonstrate the mechanisms of apoptosis induced by USP39 knockdown, the levels of cleaved cas3 and cleaved cas9 were increased in response to USP39 knockdown (XREF_FIG E, F)."
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"Besides, our experimental data revealed that knockdown of USP39 induced cell apoptosis through inhibition of AKT signaling pathway in PC cells."
28286270
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"Furthermore, USP39 silencing induced apoptosis of CAL27 cells via activations of Caspase 3 and PARP."
26835714
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"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
27456357
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"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis."
29805563
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"Flow cytometric analysis showed that USP39 knockdown induced cell cycle arrest at G2/M phase and enhanced cell apoptosis in 95D cells."
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"This data demonstrated that USP39 silencing induced apoptosis in SW1116 cells."
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"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
34987596
USP39 activates apoptotic process.
| 8
USP39 activates apoptotic process. 8 / 9
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"Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma."
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"The group of silencing USP39 increased the apoptotic cells (early apoptosis and late apoptosis) by 13-fold, as compared to the group of shCon (Additional file 1 : Figure S1A and B)."
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"Depletion of USP39 promotes apoptosis of U2OS cells."
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"Down-regulation of USP39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells [XREF_BIBR]."
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"Down-regulation of USP39 induced SMMC-7721 cells apoptosis."
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
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"Second, we found that knocking down USP39 induces apoptosis of A549 and HCC827 cells, upregulates cleaved cas3, cleaved cas9 and DNA damage makers (53BP1 and gammaH2AX) [XREF_BIBR]."
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"Knocking-down of USP39 promotes the cell apoptosis and arrest of the cell cycle, whereas SP1 forcefully reversed these effects."
34197957
USP39 affects cell cycle
| 31
USP39 inhibits cell cycle.
| 16
USP39 inhibits cell cycle. 10 / 16
| 16
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"Our loss-of-function experiments demonstrated that knockdown of the expression of USP39 repressed the proliferation of leukemia cells, induced cell cycle arrest, and cell apoptosis."
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"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
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"These results indicate that knockdown of USP39 induced G2/M phase cell cycle arrest via suppression of the CDK1 and Cyclin B1 complex."
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"To evaluate the role of cell cycle-regulatory molecules in knockdown of USP39 induced G2/M cell cycle arrest, we examined the effect of USP39 knockdown on cell cycle-regulatory molecules, including p21, CDK1 and cyclin A2."
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
26959883
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"This indicates that USP39 shRNA could strongly block (p < 0.01) the cell cycle progression of TT cells."
26303214
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"Silencing of USP39 induced cell apoptosis and cell cycle arrest at G2/M phase."
29328477
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"In addition, flow cytometry analysis in the present study identified that the knockdown of USP39 induced cell cycle arrest in the G 2 / M phases, which may have induced the inhibition of proliferation."
29556295
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"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis."
29805563
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"A further analysis indicated suppression of USP39 arrested cell cycle progression at G2/M phase via p21 dependent way."
28403900
USP39 activates cell cycle.
| 15
USP39 activates cell cycle. 10 / 15
| 15
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"Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma."
27456357
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"First, we observed that depletion of USP39 contributes to abnormal cell cycle distribution by inducing cell cycle arrest at G2/M."
33255748
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"Furthermore, suppression of USP39 arrested cell cycle progression at G 2 / M phase in SMMC-7721cells."
25889525
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"Meanwhile, knockdown of USP39 could arrest cell cycle at G2/M via cyclin dependent pathway and promoted apoptosis through PARP cleavage [XREF_BIBR - XREF_BIBR]."
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"Knockdown of endogenous USP39 expression could suppress the oncogenic properties of osteosarcoma cells and induce cell cycle arrest at G2/M phase, promote apoptosis through PARP cleavage."
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"Taken together, our findings implicate that USP39 promotes the development of human leukemia by regulating cell cycle, survival, and proliferation of the cells."
30898977
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"Knockdown of USP39 significantly decreased cell proliferation and caused cell cycle arrest at G2/M phase."
26303214
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"Taken together, these results suggest that knockdown of USP39 could inhibit TT cell proliferation by inducing G2/M phase cell cycle arrest."
26303214
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"Knockdown of USP39 induced cell cycle arrest and its effect on cell cycle-regulatory molecules."
28403900
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"This observation indicated that the cell cycle was blocked at the G2/M phase by USP39 knockdown in HL-60 cells (XREF_FIG A, B)."
30898977
USP39 is modified
17 | 2
USP39 is phosphorylated.
16 |
USP39 is phosphorylated on S82. 8 / 8
8 |
hprd
No evidence text available
18767875
hprd
No evidence text available
18452278
hprd
No evidence text available
17322306
hprd
No evidence text available
20058876
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
hprd
No evidence text available
17287340
hprd
No evidence text available
19651622
USP39 is phosphorylated on S46. 3 / 3
3 |
hprd
No evidence text available
18767875
hprd
No evidence text available
17287340
hprd
No evidence text available
17081983
USP39 is phosphorylated on S352. 1 / 1
1 |
hprd
No evidence text available
20068231
USP39 is phosphorylated on S43. 1 / 1
1 |
hprd
No evidence text available
17081983
USP39 is phosphorylated on S97. 1 / 1
1 |
hprd
No evidence text available
20068231
USP39 is phosphorylated on T357. 1 / 1
1 |
hprd
No evidence text available
20068231
USP39 is phosphorylated on S42. 1 / 1
1 |
hprd
No evidence text available
17287340
USP39 is sumoylated.
| 2
USP39 is sumoylated. 2 / 2
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"Furthermore, inhibition of the SUMOylation of USP39 can enhance the proliferation of cancer cells including breast and hepatocellular cancer via affecting the recruitment of tri-snRNP, suggesting that SUMOylation of USP39 has an essential role in cancer therapy ( xref ; xref ; xref ) ( xref )."
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"Inhibition of SUMOylation of USP39 enhanced the proliferation of cancer cells as it affected the recruitment of tri-snRNP, suggesting that SUMOylation of USP39 plays an essential role in cancer therapy ( xref ; xref )."
34177595
USP39 is acetylated.
1 |
USP39 is acetylated on K428. 1 / 1
1 |
hprd
No evidence text available
19608861
USP39 affects ZEB1
| 16
USP39 increases the amount of ZEB1.
| 6
USP39 increases the amount of ZEB1. 6 / 6
| 6
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"Our results revealed that the silencing of USP39 expression significantly suppressed ZEB1 protein expression in SK-hep-1 and HepG2 cells (Fig. 3A)."
33649471
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"Accordingly, the protein level of ZEB1 could be increased by USP39 overexpression in SK-hep-1 cell (Fig. 3B)."
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"It is interesting to speculate that whether E3 ligase TRIM26 with ubiquitin function has a common foothold with USP39, that is, TRIM26 affects the stability of ZEB1 through ubiquitination, while USP39 promotes the abnormality of ZEB1 level through deubiquitination, which orchestrates the occurrence of EMT and determines the progression of HCC.This study uncovers the elaborate ubiquitination and deubiquitination modifications of ZEB1 in HCC."
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"Since ubiquitination and stability play important roles in ZEB1 regulation, hypothetically, USP39 with the function of deubiquitination could promote HCC progression through regulating the level of ZEB1 ubiquitination.The tripartite motif (TRIM) family proteins possess one or two B-boxes along with its domain structure, and a more diverse domain at the C terminus [20, 21], which are considered key regulators of protein degradation through ubiquitylation."
33649471
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"Collectively, these results revealed a functional significance of USP39 on the ZEB1 induced EMT progression in HCC at protein levels.Interestingly, the ZEB1 mRNA level showed no significant difference in HepG2 cells transduced with shUSP39 (Fig. S2), which indicated that USP39 may mediate ZEB1 expression via posttranslational regulation (i.e., protein deubiquitination)."
33649471
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"In our study, similarly, USP39 can modulate the level of ZEB1 protein via deubiquitination."
33649471
USP39 decreases the amount of ZEB1.
| 3
USP39 decreases the amount of ZEB1. 3 / 3
| 3
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"Conversely, USP39 knockdown significantly reversed the ZEB1 protein level in SK-hep-1 after transfection with shTRIM26 (Fig. 7H)."
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"In addition, USP39 downregulation dramatically suppressed the level of ZEB1 as well as EMT progression."
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"This hypothesis was further corroborated by the fact that USP39 could reverse the effect of TRIM26 on ZEB1 expression and the progression of HCC."
33649471
USP39 ubiquitinates ZEB1.
| 2
USP39 leads to the ubiquitination of ZEB1. 2 / 2
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"Since ubiquitination and stability play important roles in ZEB1 regulation, hypothetically, USP39 with the function of deubiquitination could promote HCC progression through regulating the level of ZEB1 ubiquitination.The tripartite motif (TRIM) family proteins possess one or two B-boxes along with its domain structure, and a more diverse domain at the C terminus [20, 21], which are considered key regulators of protein degradation through ubiquitylation."
33649471
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"Clearly, the downregulation of USP39 greatly promoted ZEB1 ubiquitination in HepG2 and SK-hep-1 cells (Fig. 3F)."
33649471
USP39 deubiquitinates ZEB1.
| 2
USP39 deubiquitinates ZEB1. 2 / 2
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"Collectively, our findings suggest that the balanced deubiquitination and ubiquitination of ZEB1 by USP39 and TRIM26 represent a novel mechanism for the progression of HCC, and this discovery provides a promising strategy for targeting USP39 or TRIM26 in the treatment of HCC cases with aberrant ZEB1 expression levels."
33649471
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"USP39 promotes EMT and inhibits ZEB1 ubiquitination in HCC."
33649471
USP39 activates ZEB1.
| 2
USP39 activates ZEB1. 2 / 2
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
33649471
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"The results indicated that USP39 overexpression largely increased the half-life of the ZEB1 protein in HepG2 cells (Fig. 3D)."
33649471
USP39 inhibits ZEB1.
| 1
USP39 inhibits ZEB1. 1 / 1
| 1
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"Collectively, we believe that USP39 reduces the degradation of ZEB1 protein through direct deubiquitination, which promotes EMT progression and the development of HCC.Ubiquitination and deubiquitination are two contrasting posttranslational processes that involve in the conjugation and removing of ubiquitin from targeted proteins, respectively."
33649471
USP39 affects Neoplasm Invasiveness
| 4 11
USP39 activates Neoplasm Invasiveness.
| 4 10
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"USP39 promotes proliferation and invasion in vitro and tumor growth in vivo."
33731694
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"USP39 increases proliferation and invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice."
33731694
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"Subsequent functional experiments revealed that USP39 promoted the proliferation and invasion of ovarian cancer cells in vitro and tumor growth in vivo."
33731694
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"In addition, overexpression of HMGA2 rescued the inhibition of proliferation, invasion and xenograft growth induced by silencing USP39."
33731694
eidos
"USP39 promotes proliferation / invasion in vitro and tumor growth in vivo ."
33731694
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"Third , we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [ 31 ] ."
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"As shown in XREF_FIG A-F, USP39 knockdown reduced the cell migration and invasion of both USP39KD cells in comparison to the control cells (* p < 0.05, ** p < 0.01, **** p < 0.0001)."
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"USP39 promoted the invasion of glioma cells in vivo and reduced the overall survival of the mice."
33811456
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"Knockdown of USP39 in U251 and U87 cell lines significantly inhibited their migration and invasion in vitro ."
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"Overexpression of USP39 significantly increased the invasion ability and cell survival curve ( p < 0.05)."
36046375
USP39 inhibits Neoplasm Invasiveness. 1 / 1
| 1
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"Knockdown of USP39 in U251 and U87 cell lines significantly inhibited their migration and invasion in vitro."
33811456
USP39 affects FAM126A
| 14
USP39 activates FAM126A. 10 / 14
| 14
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"Simultaneously, USP39 knockdown inhibited the proliferation of HCC cells transfected with shTRIM26."
33649471
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"SIRT7 promotes HCC development by deacetylation of USP39."
34900376
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"Wound-healing and transwell assays confirmed that USP39 knockdown remarkably suppressed the migration capacities of HCC cells (Fig. 2F–I)."
33649471
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"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
36707504
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"The mRNA level of USP39 was significantly elevated in HCC."
34987596
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"Indeed, silencing USP39 expression markedly inhibited the proliferation and metastasis of HCC cells in vitro and in vivo experiments, indicating the potential carcinogenic effect of USP39 in HCC development."
33649471
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"However, the molecular mechanism by which USP39 promotes HCC progression has not been well defined, especially regarding its putative ubiquitination function."
33649471
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"The MTT results showed that silencing USP39 expression significantly inhibited the proliferative ability of HCC cells (Figs."
33649471
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
33649471
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"The depletion of USP39 could inhibit the proliferation and metastasis of HCC cells [11]."
34987596
USP39 affects TP53
1 | 1 9 1
USP39 inhibits TP53.
| 1 6
USP39 inhibits TP53. 7 / 7
| 1 6
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"USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53."
34822033
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"on A549 cells to confirm the key role of p53, the WB result demonstrated that exposure to PFT-alpha (30 or 40 mum/48 h) clearly inhibited the p53 pathway activation, which activated by USP39 knockdown in A549 cells."
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"Altogether, these results suggest that USP39 knockdown causes a significant accumulation of p53 via regulating both transcriptional levels and post-translational modifications of p53."
33255748
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"Moreover, depletion of USP39 blocked activation of Akt, mTOR, p53, and PARP signaling pathways."
27629785
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"Further studies demonstrated that depletion of USP39 results in an upregulation of p53 through prolonging its half-life and activating its transcriptional activation activity ."
33255748
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"Meanwhile, we found that USP39 knockdown also activates the p53 pathway, upregulation of p53, p-p53 (S15), p21 and BAX in HCC827 cells."
33255748
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"Furthermore, USP39 knockdown increased the stability of the p53 protein by prolonging its half-life."
33255748
USP39 binds TP53.
1 | 1 1
TP53 binds USP39. 3 / 3
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"Given the importance of the p53 pathway in the tumor promotor function of USP39, further investigations should address these key questions: (1) How does USP39 regulate p53 and what is the interaction between USP39 and p53? (2) is the oncogenic function of USP39 solely dependent on the p53 pathway, or is another signaling pathway involved?"
33255748
biogrid
No evidence text available
19615732
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"Given the importance of the p53 pathway in the tumor promotor function of USP39, further investigations should address these key questions : (1) How does USP39 regulate p53 and what is the interaction between USP39 and p53?"
33255748
USP39 activates TP53.
| 2
USP39 activates TP53. 2 / 3
| 2
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"The underlying mechanism is demonstrated by knocking down USP39, that results in p53 upregulation, associated with its prolonged half-life."
34822033
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"In addition, by employing a double luciferase reporter system assay, we found that depletion of USP39 enhances p53 responsive transcriptional reporter activity."
33255748
USP39 affects EGFR
| 8
USP39 activates EGFR.
| 4
USP39 activates EGFR. 4 / 6
| 4
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"To verify whether the regulatory effect of USP39 was EGFR specific, ectopic expression of USP39 were performed in PC-3 and DU145 cells, which showed that overexpressed USP39 upregulated EGFR mRNA and protein levels, indicating that EGFR is a downstream target of USP39."
26959883
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"It was found in our previous study that USP39 knockdown could inhibit the abnormal proliferation of prostate cancer cells by inhibiting the splicing maturation and transcriptional prolongation of EGFR mRNA [16]."
34544400
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"We hypothesized that USP39 could up-regulate EGFR by increasing the pre-mRNA splicing."
26959883
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"The results demonstrated that the level of the 3 '-end of EGFR decreased (P = 0.0015) more sharply than that of the 5 '-end (P = 0.0069), and the ratio ofthe 3 '-end to 5 '-end levels was significant decreased (P = 0.0297), implying that knockdown of USP39 might inhibit the transcription elongation of EGFR, and might produce unstable EGFR mRNA fragments lacking the 3 '-UTR."
26959883
USP39 increases the amount of EGFR.
| 3
USP39 increases the amount of EGFR. 2 / 3
| 2
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"Microarray analysis suggested that knockdown of USP39 caused a reduced expression of EGFR."
26959883
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"Silencing of USP39 inhibited the expression of EGFR 3 '-end, and presented a remarkable block to the maturation of EGFR mRNA, suggesting that silencing of USP39 decreased the transcriptional elongation and maturation of EGFR mRNA."
26959883
Modified USP39 increases the amount of EGFR. 1 / 1
| 1
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"Consistently, overexpression of USP39 upregulated EGFR expression both in both mRNA levels (PC-3 :P = 0.0258; DU145 :P = 0.0426) and protein levels."
26959883
USP39 decreases the amount of EGFR.
| 1
USP39 decreases the amount of EGFR. 1 / 2
| 1
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"Knockdown of USP39 downregulated EGFR expression in PC-3 and DU145 cells in mRNA (P < 0.0001 and P < 0.0001, respectively) and protein levels."
26959883
USP39 affects Neoplasm Metastasis
| 1 10
USP39 activates Neoplasm Metastasis.
| 9
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"Thus, depletion of USP39 could inhibit the proliferation and metastasis of HCC cells."
34987596
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"USP39 knockdown also suppressed the shTRIM26-related HCC cell metastasis."
33649471
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"The depletion of USP39 could inhibit the proliferation and metastasis of HCC cells [11]."
34987596
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"Together, these data demonstrate that USP39 knockdown inhibits the metastasis of lung cancer cells in vivo and in vitro."
33255748
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"The results showed that USP39 knockdown led to an obvious reduction in tumor metastasis, while TRIM26 downregulation enhanced the tumor metastasis and reversed the reduction of shUSP39-related cell metastasis and the number of nodules in the lung (Fig. 8G, H)."
33649471
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"For instance, USP39 promotes colorectal cancer growth and metastasis through the Wnt and beta-catenin pathway [XREF_BIBR]."
30898977
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
33649471
reach
"Indeed, silencing USP39 expression markedly inhibited the proliferation and metastasis of HCC cells in vitro and in vivo experiments, indicating the potential carcinogenic effect of USP39 in HCC development."
33649471
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"USP39 promotes colorectal cancer growth and metastasis through the Wnt and beta-catenin pathway."
28259917
USP39 inhibits Neoplasm Metastasis.
| 1 1
USP39 inhibits Neoplasm Metastasis. 2 / 2
| 1 1
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
33649471
trips
"Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway."
33255748
USP39 affects cell growth
| 9 1
USP39 inhibits cell growth.
| 4 1
USP39 inhibits cell growth. 5 / 5
| 4 1
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"Depletion of USP39 by siRNA significantly suppressed cell growth and decreased invasive capacity of RCC cells."
29328477
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"Previous studies found that down-regulation of USP39 could inhibit cell growth and colony formation of human breast cancer cells [XREF_BIBR]."
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"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis ( xref )."
29805563
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"USP39 knockdown inhibited cell proliferation and colony formation in vitro in the HepG2 cells, while upregulation of USP39 promoted tumor cell growth."
26081192
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"Recently, scientists reported aberrant USP39 expression could inhibit breast cancer cell growth in vitro [XREF_BIBR], however, little is known about how USP39 functions in human osteosarcoma and whether it can be used as an potential therapeutic target."
28403900
USP39 activates cell growth.
| 5
USP39 activates cell growth. 5 / 5
| 5
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"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis."
29805563
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"In osteosarcoma cells, a decreased USP39 expression inhibited cell growth and induced apoptosis."
29805563
reach
"In conclusion, the inhibition of USP39 in CAL27 cells suppressed cell growth probably via induction cell cycle arrest and apoptosis."
26835714
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"These findings are in agreement with cell growth inhibition, which suggest that USP39 could modulate osteosarcoma cell growth via cell cycle control."
28403900
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"In conclusion, knockdown of USP39 by RNAi inhibited cell growth due to inactivation of the CDK1 and CyclinB complex."
26303214
USP39 affects Neoplasms
| 3 6
USP39 activates Neoplasms.
| 3 4
USP39 activates Neoplasms. 7 / 7
| 3 4
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"The downregulation of USP39 expression in HCC cells significantly inhibited tumor growth, by reducing the volume and weight of tumors (Fig. 8A–C)."
33649471
reach
"Conversely, USP39 knockdown inhibited proliferation in tumor size and weight of SK-hep-1 cells transfected with shTRIM26."
33649471
eidos
"USP39 depletion led to reduced tumor mass and volume ( Fig. 3B ) ."
33731694
eidos
"USP39 promotes tumor progression by increasing HMGA2 levels in ovarian cancer cells We next investigated the functional significance of the USP39-HMGA2 axis ."
33731694
eidos
"USP39 promotes tumor progression by increasing HMGA2 levels in ovarian cancer cells ."
33731694
reach
"The results showed that USP39 knockdown led to an obvious reduction in tumor metastasis, while TRIM26 downregulation enhanced the tumor metastasis and reversed the reduction of shUSP39-related cell metastasis and the number of nodules in the lung (Fig. 8G, H)."
33649471
reach
"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
36707504
USP39 inhibits Neoplasms.
| 2
USP39 inhibits Neoplasms. 2 / 2
| 2
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"The downregulation of USP39 expression in HCC cells significantly inhibited tumor growth, by reducing the volume and weight of tumors (Fig. 8A–C)."
33649471
reach
"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
34987596
USP39 affects Circulin-C
| 8
sparser
"However, the role of circRNA hsa_circ_0055440 (circ-USP39) in acute myocardial infarction regulation has not been studied yet."
37005321
sparser
"Silencing of circ-USP39 alleviates hypoxia-induced cardiomyocyte injury via the miR-499b-5p/ACSL1 axis."
37005321
sparser
"The head-to-tail splicing of circ-USP39 was verified by agarose gel electrophoresis."
37005321
sparser
"This study aims to explore the effect of circ-USP39 on hypoxia-induced cardiomyocyte injury."
37005321
sparser
"The interactions between miR-499b-5p and circ-USP39 (or acyl-CoA synthetase long-chain family member-1 (ACSL1) ) were verified by luciferase reporter assays."
37005321
sparser
"After confirming the circular characteristics of circ-USP39, we further found that the circ-USP39 expression was upregulated in hypoxia-induced cardiomyocytes and the circ-USP39 knockdown facilitated the viability of hypoxia-induced AC16, while suppressing cardiomyocyte apoptosis and injury."
37005321
sparser
"Importantly, circ-USP39 negatively regulated miR-499b-5p expression."
37005321
sparser
"As a downstream target of miR-499b-5p, ACSL1 partially counteracted the protective effect of circ-USP39 depletion on cardiomyocyte injury."
37005321
USP39 affects VEGFA
| 5 1
USP39 decreases the amount of VEGFA.
| 2
USP39 decreases the amount of VEGFA. 2 / 2
| 2
reach
"USP39 knockdown upregulated the expression of VEGF-A 165b , and USP39 overexpression downregulated the expression of VEGF-A 165b significantly (both P < 0.05)."
34544400
reach
"On the contrary, RCC cells with overexpression of USP39 downregulated the expression of VEGF-A ."
34544400
USP39 activates VEGFA.
| 2
USP39 activates VEGFA. 2 / 2
| 2
reach
"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
34544400
reach
"This potentially originating from the iUSP domain cannot bind ubiquitin either, and the ZnF of USP39 could interact with the splicing independent on ubiquitin [64], which provides the opportunity for SRSF1 binding to USP39 , though further exploration is required to confirm the conclusion.Firstly, one remaining limitation is how USP39 drives the changes in VEGF-A , which needs further research to elucidate the specific mechanisms."
34544400
USP39 increases the amount of VEGFA.
| 1
USP39 increases the amount of VEGFA. 1 / 1
| 1
reach
"Knockdown or overexpression of USP39 either upregulates or downregulates VEGF-A 165b expression."
34544400
USP39 binds VEGFA.
| 1
VEGFA binds USP39. 1 / 1
| 1
sparser
"The interaction between USP39 and VEGF-A alternative splicing was assessed by affinity purification and mass spectrometry, co-immunoprecipitation and Western blot assays."
34544400
MYC affects USP39
| 1 4 1
MYC increases the amount of USP39.
| 3
MYC increases the amount of USP39. 3 / 3
| 3
reach
"In contrast, inhibition of c-MYC by shRNA decreased USP39 expression."
33731694
reach
"As expected, overexpression of c-MYC significantly increased USP39 expression at both the RNA and protein level."
33731694
reach
"C-MYC activates the transcription of USP39 in ovarian cancer cells."
33731694
MYC activates USP39.
| 1 1 1
MYC activates USP39. 3 / 3
| 1 1 1
sparser
"Importantly, USP39 was transcriptionally activated by the oncogene protein c-MYC in ovarian cancer cells."
33731694
reach
"The effect of c-MYC on USP39 expression was further investigated by performing a luciferase assay, and the result showed that forced expression of c-MYC increased luciferase activity of the USP39 promoter reporter containing the wild-type but not the mutant c-MYC binding site."
33731694
eidos
"In contrast , inhibition of c-MYC by shRNA decreased USP39 expression ( Fig. 4A-B ) ."
33731694
USP39 affects TRIM26
1 | 4
USP39 binds TRIM26.
1 | 3
TRIM26 binds USP39. 4 / 4
1 | 3
biogrid
No evidence text available
23105109
reach
"Co-immunoprecipitation assays showed a direct interaction between endogenous USP39 and TRIM26 in SK-hep-1 cells (Fig. 4A)."
33649471
reach
"In addition, a direct interaction between USP39 and TRIM26 was identified by co-immunoprecipitation and immunofluorescence staining assays, respectively."
33649471
reach
"To further confirm the interaction between USP39 and TRIM26, co-transfection with HA-USP39 and Myc-TRIM26 expressing plasmids were conducted in SK-hep-1 cell."
33649471
USP39 inhibits TRIM26.
| 1
USP39 inhibits TRIM26. 1 / 1
| 1
reach
"We hypothesized that USP39 antagonizes TRIM26 in targeting ZEB1 for ubiquitin-dependent proteasomal degradation, to regulate the proliferation and migration of HCC cells."
33649471
USP39 affects CDKN1A
| 4 1
USP39 inhibits CDKN1A.
| 2
USP39 inhibits CDKN1A. 2 / 2
| 2
reach
"Meanwhile, we found that USP39 knockdown also activates the p53 pathway, upregulation of p53, p-p53 (S15), p21 and BAX in HCC827 cells."
33255748
reach
"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
33255748
USP39 increases the amount of CDKN1A.
| 1
Mutated USP39 increases the amount of CDKN1A. 1 / 1
| 1
reach
"Gene expression profiling of usp39 mutants revealed decreased rb1 and increased e2f4, rbl2 (p130), and cdkn1a (p21) expression."
21249182
USP39 binds CDKN1A.
| 1
CDKN1A binds CDKN1B, USP39, and BAX. 1 / 1
| 1
sparser
"In addition, USP39 silencing was associated with the increased expressions of p21, p27, and Bax."
27456357
USP39 activates CDKN1A.
| 1
USP39 activates CDKN1A. 1 / 1
| 1
reach
"USP39 mediates p21 dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis."
33634905
TRIM26 affects USP39
1 | 4
TRIM26 binds USP39.
1 | 3
TRIM26 binds USP39. 4 / 4
1 | 3
biogrid
No evidence text available
23105109
reach
"Co-immunoprecipitation assays showed a direct interaction between endogenous USP39 and TRIM26 in SK-hep-1 cells (Fig. 4A)."
33649471
reach
"In addition, a direct interaction between USP39 and TRIM26 was identified by co-immunoprecipitation and immunofluorescence staining assays, respectively."
33649471
reach
"To further confirm the interaction between USP39 and TRIM26, co-transfection with HA-USP39 and Myc-TRIM26 expressing plasmids were conducted in SK-hep-1 cell."
33649471
TRIM26 activates USP39.
| 1
TRIM26 activates USP39. 1 / 1
| 1
reach
"Furthermore, TRIM26 silencing could significantly reverse the reduction of USP39 knockdown cell proliferation, in tumor size and weight (Fig. 8B, C)."
33649471
Bisphenol A affects USP39
4 |
Bisphenol A decreases the amount of USP39.
3 |
Bisphenol A decreases the amount of USP39. 3 / 3
3 |
ctd
No evidence text available
29275510
ctd
No evidence text available
30816183
ctd
No evidence text available
25181051
Bisphenol A increases the amount of USP39.
1 |
Bisphenol A increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
28628672
USP39 affects USP4
| 2 2
USP39 binds USP4.
| 1 2
USP4 binds USP39. 1 / 1
| 1
sparser
"As USP39 forms a stable complex with USP4 in cells ( xref ; xref ), it is a prime candidate for an activating role in vivo ."
21415856
USP4 binds USP39 and UBL. 1 / 1
| 1
sparser
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [ xref , xref ], implying that USP39 might be deubiquitylating USP4."
28659380
USP4 binds USP39 and UBL domain. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 deubiquitinates USP4.
| 1
USP39 deubiquitinates USP4. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 affects Thr-Thr
| 4
USP39 inhibits Thr-Thr.
| 2
USP39 inhibits Thr-Thr. 2 / 2
| 2
reach
"This indicates that USP39 shRNA could strongly block (p < 0.01) the cell cycle progression of TT cells."
26303214
reach
"Knockdown of USP39 significantly inhibited proliferation of TT cells in vitro."
26303214
USP39 activates Thr-Thr.
| 2
USP39 activates Thr-Thr. 2 / 2
| 2
reach
"This indicates that knockdown of USP39 could strongly decrease the proliferation of TT cells."
26303214
reach
"Taken together, these results suggest that knockdown of USP39 could inhibit TT cell proliferation by inducing G2/M phase cell cycle arrest."
26303214
USP39 affects SRSF1
| 4
USP39 binds SRSF1.
| 3
SRSF1 binds USP39. 3 / 3
| 3
reach
"The interaction between USP39 and SRPK1/SRSF1 was analyzed by Western blot using anti-Flag tag (Abcam) or anti-SRSF1 (Abcam)."
34544400
reach
"This potentially originating from the iUSP domain cannot bind ubiquitin either, and the ZnF of USP39 could interact with the splicing independent on ubiquitin [64], which provides the opportunity for SRSF1 binding to USP39 , though further exploration is required to confirm the conclusion.Firstly, one remaining limitation is how USP39 drives the changes in VEGF-A , which needs further research to elucidate the specific mechanisms."
34544400
reach
"The same binding site was found in the interaction between USP39 and SRSF1 (Fig. 5E)."
34544400
USP39 phosphorylates SRSF1.
| 1
USP39 leads to the phosphorylation of SRSF1. 1 / 1
| 1
reach
"In addition, there was stronger phosphorylation of SRSF1 in 786-O and ACHN cells with overexpression of USP39, and knockdown of USP39 in RCC cells could inhibit phosphorylation of SRSF1 (Fig. 6C, D)."
34544400
USP39 affects RB1
| 4
USP39 activates RB1.
| 3
USP39 activates RB1. 3 / 3
| 3
reach
"Our studies reveal a novel role of usp39 mediated mRNA splicing of rb1 in pituitary cell growth control, which is critical for maintaining embryonic pituitary homeostasis."
21249182
reach
"It showed that the down-regulation of USP39 gene can cause rb1 mRNA splicing abnormalities, which then leaded to downstream target genes e2f4 up-regulated in zebrafish."
25889525
reach
"We then performed an rb1 mRNA overexpression experiment in usp39 mutants and observed partial rescue of the adenohypophysis phenotype (XREF_FIG, mutant N = 34, ~ 50% showed rescue), validating the importance of usp39 mediated rb1 mRNA splicing in controlling pituitary lineage expansion during development."
21249182
USP39 inhibits RB1.
| 1
USP39 inhibits RB1. 1 / 1
| 1
reach
"Silencing of USP39 could specifically reduce the Aurora B mRNA expression [XREF_BIBR], and mutation of zebrafish USP39 induces rb1 splicing defects and pituitary lineage expansion [XREF_BIBR]."
26959883
USP39 affects HMGA2
| 2 2
USP39 binds HMGA2.
| 1 2
USP39 binds HMGA2. 3 / 3
| 1 2
sparser
"We next investigated the functional significance of the USP39-HMGA2 axis."
33731694
reach
"Consistent with this, USP39 bound to biotin labeled HMGA2 in an RNA pull-down assay, indicating a direct interaction between USP39 and HMGA2."
33731694
sparser
"Consistent with this, USP39 bound to biotin-labeled HMGA2 in an RNA pull-down assay (Fig. xref ), indicating a direct interaction between USP39 and HMGA2."
33731694
USP39 increases the amount of HMGA2.
| 1
USP39 increases the amount of HMGA2. 1 / 1
| 1
reach
"Ectopic expression of USP39 increased the mRNA and protein levels of HMGA2, whereas USP39 knockdown had the opposite effect."
33731694
USP39 affects FOXM1
| 2 2
USP39 binds FOXM1.
| 2
USP39 binds FOXM1. 2 / 2
| 2
sparser
"The interaction between USP39 and FOXM1 was investigated using co-immunoprecipitation (co-IP) and in vitro deubiquitination analysis."
36119839
sparser
"In general, our research revealed the USP39-FOXM1 axis as a critical driver of breast cancer cell proliferation and provided a theoretical foundation for targeting the USP39-FOXM1 axis for pancreatic cancer treatment."
36119839
USP39 activates FOXM1.
| 2
USP39 activates FOXM1. 2 / 2
| 2
reach
"Inhibition of USP39 by siRNA has downregulated FOXM1 and in turn led to tumor volume reduction in xenograft model of HCC."
33680951
reach
"The results suggest that knockdown of USP39 inhibits the growth of HCC in vitro and in vivo, potentially through the induction of G2/M arrest by regulating the pre-mRNA splicing of FoxM1."
28413501
USP4 affects USP39
| 1 2
USP4 binds USP39. 1 / 1
| 1
sparser
"As USP39 forms a stable complex with USP4 in cells ( xref ; xref ), it is a prime candidate for an activating role in vivo ."
21415856
USP4 binds USP39 and UBL. 1 / 1
| 1
sparser
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [ xref , xref ], implying that USP39 might be deubiquitylating USP4."
28659380
USP4 binds USP39 and UBL domain. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 affects cell migration
| 1 2
USP39 activates cell migration. 3 / 3
| 1 2
reach
"Third, we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [XREF_BIBR]."
33255748
eidos
"Third , we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [ 31 ] ."
33255748
reach
"As shown in XREF_FIG A-F, USP39 knockdown reduced the cell migration and invasion of both USP39KD cells in comparison to the control cells (* p < 0.05, ** p < 0.01, **** p < 0.0001)."
33255748
USP39 affects angiogenesis
| 3
USP39 activates angiogenesis. 3 / 3
| 3
reach
"These findings indicated that knockdown or overexpression of USP39 could either inhibit or promote angiogenesis of endothelial cells."
34544400
reach
"To explore the potential mechanism of USP39-mediated angiogenesis and malignant proliferation, affinity purification–mass spectrometry (AP-MS) was used to explore the interactions between USP39 and the potential target protein."
34544400
reach
"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
34544400
USP39 affects PRPF4
3 |
PRPF4 binds USP39. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26496610
USP39 affects Interferon
| 3
USP39 activates Interferon. 3 / 3
| 3
reach
"Intriguingly, USP39 promotes IFN-mediated antiviral responses by decreasing K6-linked but not canonical K48-linked polyubiquitination of STAT1 for degradation (118), eventhough K6-linked ubiquitin chains are often related to DNA damage instead of protein degradation (142)."
34707613
reach
"Mechanistically, USP39 does not affect the production of type I IFN but significantly promotes JAK and STAT downstream of type I signaling by enhancing IFN stimulated response elements promoter activity and expression of IFN stimulated genes."
33127822
reach
"Unlike USP2A, the deubiquitinating enzymes BRCC36, USP13, and USP39 positively regulate IFN activities by attenuating the polyubiquitination level of STAT1, and this process is independent of IFN treatment, which suggests divergent functional roles of these DUBs under differential contexts.Additionally, ATXN3 does not affect IFN-I production during viral infection but positively regulates IFNAR1-mediated downstream signaling by targeting HDAC3 (108)."
34707613
USP39 affects Carcinogenesis
| 2 1
USP39 activates Carcinogenesis. 3 / 3
| 2 1
eidos
"USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma ."
34197957
reach
"An increasing amount of evidence has demonstrated that the aberrant expression of USP39 promotes tumorigenesis and is associated with HCC progression [13, 14]."
33649471
eidos
"Furthermore , our study adds ESCC to the list of cancers where USP39 contributes to tumorigenesis and progression ."
34123832
USP39 affects CDK4
| 3
USP39 decreases the amount of CDK4.
| 2
USP39 decreases the amount of CDK4. 2 / 2
| 2
reach
"Knockdown of USP39 in VSMCs inhibited cyclinD1 and CDK4 protein expression compared with transfection with control siRNA (XREF_FIG), which are essential proteins for G1/S phase transformation."
28447728
reach
"Knockdown of USP39 inhibits VSMC proliferation and the expression of cyclin D1 and CDK4."
28447728
USP39 increases the amount of CDK4.
| 1
USP39 increases the amount of CDK4. 1 / 1
| 1
reach
"Furthermore, knockdown of USP39 inhibited VSMC cell proliferation and the expression of cyclin D1 and cyclin dependent kinase 4, as analyzed via cell counting, MTT assay and western blotting."
28447728
USP39 affects CD2BP2
3 |
CD2BP2 binds USP39. 3 / 3
3 |
biogrid
No evidence text available
17353931
biogrid
No evidence text available
28561026
biogrid
No evidence text available
19615732
USP39 affects BAX
| 2 1
USP39 inhibits BAX.
| 2
USP39 inhibits BAX. 2 / 2
| 2
reach
"Meanwhile, we found that USP39 knockdown also activates the p53 pathway, upregulation of p53, p-p53 (S15), p21 and BAX in HCC827 cells."
33255748
reach
"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
33255748
USP39 binds BAX.
| 1
CDKN1A binds CDKN1B, USP39, and BAX. 1 / 1
| 1
sparser
"In addition, USP39 silencing was associated with the increased expressions of p21, p27, and Bax."
27456357
USP39 affects ADAM9
| 2 1
USP39 increases the amount of ADAM9.
| 1
USP39 increases the amount of ADAM9. 1 / 1
| 1
reach
"Altogether, our data shows that USP39 induces mRNA maturation and elevates the expression of ADAM9 in glioma cells and may thus be considered as potential target for treating patients with glioma."
33811456
USP39 binds ADAM9.
| 1
USP39 binds ADAM9. 1 / 1
| 1
sparser
"Furthermore, to determine whether USP39 could interact with ADAM9 and regulate the ubiquitination of ADAM9, we co‐transfected Myc‐tagged USP39, Flag‐tagged ADAM9 with or without HA tagged Ub plasmids into HEK293T cells; co‐immunoprecipitation experiments revealed that USP39 failed to interact with ADAM9 at the protein level (Fig.  xref ) and overexpressing USP39 had no effect on the polyubiquitination of ADAM9 (Fig. S9B)."
33811456
USP39 activates ADAM9.
| 1
USP39 activates ADAM9. 1 / 1
| 1
reach
"Further on, USP39 induced ADAM9 mRNA maturation and decreased the expression of integrin beta1."
33811456
TP53 affects USP39
1 | 1 1
TP53 binds USP39. 3 / 3
1 | 1 1
sparser
"Given the importance of the p53 pathway in the tumor promotor function of USP39, further investigations should address these key questions: (1) How does USP39 regulate p53 and what is the interaction between USP39 and p53? (2) is the oncogenic function of USP39 solely dependent on the p53 pathway, or is another signaling pathway involved?"
33255748
biogrid
No evidence text available
19615732
reach
"Given the importance of the p53 pathway in the tumor promotor function of USP39, further investigations should address these key questions : (1) How does USP39 regulate p53 and what is the interaction between USP39 and p53?"
33255748
SRSF1 affects USP39
| 3
SRSF1 binds USP39. 3 / 3
| 3
reach
"The interaction between USP39 and SRPK1/SRSF1 was analyzed by Western blot using anti-Flag tag (Abcam) or anti-SRSF1 (Abcam)."
34544400
reach
"This potentially originating from the iUSP domain cannot bind ubiquitin either, and the ZnF of USP39 could interact with the splicing independent on ubiquitin [64], which provides the opportunity for SRSF1 binding to USP39 , though further exploration is required to confirm the conclusion.Firstly, one remaining limitation is how USP39 drives the changes in VEGF-A , which needs further research to elucidate the specific mechanisms."
34544400
reach
"The same binding site was found in the interaction between USP39 and SRSF1 (Fig. 5E)."
34544400
PRPF4 affects USP39
3 |
PRPF4 binds USP39. 3 / 3
3 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26496610
HMGA2 affects USP39
| 1 2
USP39 binds HMGA2. 3 / 3
| 1 2
sparser
"We next investigated the functional significance of the USP39-HMGA2 axis."
33731694
reach
"Consistent with this, USP39 bound to biotin labeled HMGA2 in an RNA pull-down assay, indicating a direct interaction between USP39 and HMGA2."
33731694
sparser
"Consistent with this, USP39 bound to biotin-labeled HMGA2 in an RNA pull-down assay (Fig. xref ), indicating a direct interaction between USP39 and HMGA2."
33731694
E2F4 affects USP39
| 3
E2F4 activates USP39.
| 2
E2F4 activates mutated USP39. 2 / 2
| 2
reach
"Consequently, e2f4 upregulation in usp39 mutants may contribute to increased proliferation of terminally differentiated pituitary cells leading to lineage expansion as seen in our BrdU studies (XREF_SUPPLEMENTARY)."
21249182
reach
"In addition, we performed quantitative RT-PCR analysis on the rb1 mRNA injected usp39 embryos and observed a 30% reduction of e2f4 expression compared to control uninjected usp39 mutants (XREF_SUPPLEMENTARY), indicating that e2f4 upregulation in usp39 mutant is secondary to Rb1 loss of function."
21249182
E2F4 inhibits USP39.
| 1
E2F4 inhibits mutated USP39. 1 / 1
| 1
reach
"In addition, knockdown of e2f4 partially rescued pomc lineage expansion in usp39 mutants."
21249182
CD2BP2 affects USP39
3 |
CD2BP2 binds USP39. 3 / 3
3 |
biogrid
No evidence text available
17353931
biogrid
No evidence text available
28561026
biogrid
No evidence text available
19615732
Methyl methanesulfonate increases the amount of USP39. 2 / 2
2 |
ctd
No evidence text available
23649840
ctd
No evidence text available
26011545
ZRANB2 affects USP39
1 | 1
ZRANB2 binds USP39. 2 / 2
1 | 1
biogrid
No evidence text available
19615732
reach
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article shows instead the interaction between ZRANB1 and USP39."
23118479
ZRANB1 affects USP39
| 1 1
ZRANB1 binds USP39. 2 / 2
| 1 1
reach
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article shows instead the interaction between ZRANB1 and USP39."
23118479
sparser
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article ( xref ) shows instead the interaction between ZRANB1 and USP39."
23118479
USP39 activates transcription, DNA-templated. 2 / 2
| 2
reach
"In addition, USP39 overexpression could promote SRPK1 phosphorylation of SRSF1, while knockdown of USP39 worked oppositely, confirming that USP39 and SRPK1 play a role through direct binding rather than affecting their transcription or translation."
34544400
reach
"The results demonstrated that the level of the 3 '-end of EGFR decreased (P = 0.0015) more sharply than that of the 5 '-end (P = 0.0069), and the ratio ofthe 3 '-end to 5 '-end levels was significant decreased (P = 0.0297), implying that knockdown of USP39 might inhibit the transcription elongation of EGFR, and might produce unstable EGFR mRNA fragments lacking the 3 '-UTR."
26959883
USP39 affects syd-2
| 2
USP39 phosphorylates syd-2. 2 / 2
| 2
reach
"We conclude that SAD-1 phosphorylates SYD-2 at developing synapses, enabling its phase separation and active zone assembly."
37398223
reach
"We determine SAD-1 phosphorylation of SYD-2 at three sites is critical to activate its phase separation."
37398223
USP39 affects splicing efficiency HMGA2
| 2
USP39 activates splicing efficiency HMGA2. 2 / 2
| 2
eidos
"Surprisingly , our work here demonstrated that USP39 improved splicing efficiency of HMGA2 rather than exon skipping ."
33731694
eidos
"Consistent with this , loss of USP39 led to decreased splicing efficiency of HMGA2 at both the 5 ' and 3 ' splice sites ( Fig. 7C ) ."
33731694
USP39 inhibits phenazine-1-carboxylate. 1 / 1
| 1
reach
"Knockdown of USP39 inhibits malignant transformation of PCa through interrupting the transcription elongation, maturation and stability of EGFR mRNA."
26959883
reach
"Here we identified that USP39 promoted tumorigenesis of PCa through activating EGFR pathway."
26959883
USP39 affects miR-133a
| 2
USP39 inhibits miR-133a. 2 / 2
| 2
reach
"Therefore, depletion of USP39 reversed the partial function of miR-133a."
29805563
reach
"USP39 is a direct target of miR-133a and partially reversed function of miR-133a."
29805563
USP39 affects invasion potential ovarian cancer cells
| 2
USP39 activates invasion potential ovarian cancer cells. 2 / 2
| 2
eidos
"D Matrigel invasion data showing that overexpression of USP39 significantly enhanced invasion capacity , whereas knockdown of USP39 ( sh-1 and sh-2 ) decreased the invasion potential of ovarian cancer cells ( n = 3 biologically independent samples ) ."
33731694
eidos
"In addition , a transwell invasion assay revealed that forced expression of USP39 significantly enhanced the invasion capacity whereas knockdown of USP39 decreased the invasion potential of ovarian cancer cells ( Fig. 2D ) ."
33731694
USP39 affects invasion ovarian cancer cells
| 2
USP39 activates invasion ovarian cancer cells. 2 / 2
| 2
eidos
"Subsequent functional experiments revealed that USP39 promoted the proliferation and invasion of ovarian cancer cells in vitro ( Fig. 2 ) and tumor growth in vivo ( Fig. 3 ) ."
33731694
eidos
"USP39 increases proliferation / invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice We next explored whether USP39 was functionally relevant for ovarian progression ."
33731694
USP39 affects growth
| 1 1
USP39 inhibits growth. 1 / 1
| 1
trips
"Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway."
33255748
USP39 inhibits growth. 1 / 1
| 1
sparser
"Moreover, knockdown of USP39 inhibited ovarian tumor growth in a xenograft model."
31637536
reach
"In addition, USP39 downregulation could inhibit the EMT phenotype in HCC cells (Fig. 3C)."
33649471
reach
"Our previous studies have shown that overexpressed USP39 can promote the proliferation and migration of human ovarian cancer by targeting EMT [15]."
33649471
USP39 affects cytokinesis
| 2
USP39 inhibits cytokinesis.
| 1
USP39 inhibits cytokinesis. 1 / 1
| 1
reach
"A previous study indicated that USP39 silencing induced defective chromosome segregation and cytokinesis in U2OS cells, indicating USP39 is critical in the regulation of mitosis."
29556295
USP39 activates cytokinesis.
| 1
USP39 activates cytokinesis. 1 / 1
| 1
reach
"As a confirmed spliceosome factor, USP39 is critical to maintain the spindle checkpoint and promote successful cytokinesis through the regulation of Aurora B mRNA splicing in mammalian cells."
29556295
USP39 affects carboplatin
| 2
USP39 activates carboplatin. 2 / 2
| 2
reach
"USP39 promotes ovarian cancer malignant phenotypes and carboplatin chemoresistance."
31180526
reach
"Another member of the USP family, USP39, was reported to promote OC malignant phenotypes and carboplatin chemoresistance."
33576437
USP39 affects ZRANB2
1 | 1
ZRANB2 binds USP39. 2 / 2
1 | 1
biogrid
No evidence text available
19615732
reach
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article shows instead the interaction between ZRANB1 and USP39."
23118479
USP39 affects ZRANB1
| 1 1
ZRANB1 binds USP39. 2 / 2
| 1 1
reach
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article shows instead the interaction between ZRANB1 and USP39."
23118479
sparser
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article ( xref ) shows instead the interaction between ZRANB1 and USP39."
23118479
USP39 affects XRCC1
| 2
USP39 inhibits XRCC1. 2 / 2
| 2
reach
"USP39 downregulation could inhibit RCC cell proliferation and progression, suggesting that USP39 may prove to be a potential target for inhibiting RCC."
34544400
reach
"In addition, USP39 knockdown was found to inhibit RCC progression through blocking Akt/ERK pathways [22]."
34544400
USP39 affects TRIM25
2 |
TRIM25 binds USP39. 2 / 2
2 |
biogrid
No evidence text available
29117863
biogrid
No evidence text available
23105109
USP39 affects SRPK1
1 | 1
SRPK1 binds USP39. 2 / 2
1 | 1
reach
"The interaction between USP39 and SRPK1/SRSF1 was analyzed by Western blot using anti-Flag tag (Abcam) or anti-SRSF1 (Abcam)."
34544400
biogrid
No evidence text available
23602568
USP39 affects SP1
1 | 1
USP39 deubiquitinates SP1.
| 1
USP39 leads to the deubiquitination of SP1. 1 / 1
| 1
reach
"USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma."
34197957
USP39 binds SP1.
1 |
SP1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
20195357
USP39 affects PRPF4B
2 |
PRPF4B binds USP39. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23602568
USP39 affects PARP1
| 1
USP39 inhibits PARP1. 1 / 2
| 1
reach
"Moreover, depletion of USP39 blocked activation of Akt, mTOR, p53, and PARP signaling pathways."
27629785
USP39 affects Glioma
| 2
USP39 inhibits Glioma.
| 1
USP39 inhibits Glioma. 1 / 1
| 1
reach
"Additionally, overexpression of Cyclin B1 rescues the arrested cell cycle at G2/M transition and the suppressed proliferation of glioma cells caused by USP39 knockdown in vitro."
37302347
USP39 activates Glioma.
| 1
USP39 activates Glioma. 1 / 1
| 1
reach
"Furthermore, USP39 promotes the growth of glioma xenograft in subcutaneous and in situ of nude mice."
37302347
USP39 affects ERK
| 2
USP39 phosphorylates ERK.
| 1
Modified USP39 leads to the phosphorylation of ERK. 1 / 1
| 1
reach
"Furthermore, the inhibition of USP39 expression decreased the phosphorylation of extracellular signal regulated kinase (ERK) 1/2, indicating that ERK signaling pathways might be involved in the regulation of melanoma cell proliferation by USP39."
27456357
USP39 inhibits ERK.
| 1
USP39 inhibits ERK. 1 / 1
| 1
reach
"Mechanistically, downregulation of USP39 blocked the activation of Akt and extracellular signal regulated kinase signaling pathways in RCC cells."
29328477
USP39 affects CDK1
| 2
USP39 inhibits CDK1.
| 1
USP39 inhibits CDK1. 1 / 1
| 1
reach
"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
33255748
USP39 increases the amount of CDK1.
| 1
USP39 increases the amount of CDK1. 1 / 1
| 1
reach
"Besides, both the phosphorylated and basal levels of CDK1 were reduced by USP39 knockdown."
26303214
USP39 affects CCNB1
| 2
USP39 deubiquitinates CCNB1.
| 1
USP39 deubiquitinates CCNB1. 1 / 1
| 1
reach
"USP39 interacts with Cyclin B1 and stabilizes its expression by deubiquitinating Cyclin B1."
37302347
USP39 activates CCNB1.
| 1
USP39 activates CCNB1. 1 / 1
| 1
reach
"USP39 mediates p21 dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis."
33634905
USP39 affects AKT
| 2
USP39 inhibits AKT. 2 / 2
| 2
reach
"Mechanistically, downregulation of USP39 blocked the activation of Akt and extracellular signal regulated kinase signaling pathways in RCC cells."
29328477
reach
"Moreover, depletion of USP39 blocked activation of Akt, mTOR, p53, and PARP signaling pathways."
27629785
TRIM25 affects USP39
2 |
TRIM25 binds USP39. 2 / 2
2 |
biogrid
No evidence text available
29117863
biogrid
No evidence text available
23105109
SRPK1 affects USP39
1 | 1
SRPK1 binds USP39. 2 / 2
1 | 1
reach
"The interaction between USP39 and SRPK1/SRSF1 was analyzed by Western blot using anti-Flag tag (Abcam) or anti-SRSF1 (Abcam)."
34544400
biogrid
No evidence text available
23602568
SIRT7 affects USP39
| 2
SIRT7 deacetylates USP39. 2 / 2
| 2
reach
"Notably, the deacetylation of USP39 by SIRT7 promotes its stability and thereby accelerates HCC cell proliferation and tumorigenesis invitro and invivo."
32711345
reach
"Our data demonstrated a novel mechanism by which SIRT7 modulates the deacetylation of USP39 to promote HCC development, thus providing an effective anti-tumor therapeutic strategy for HCC."
32711345
PRPF4B affects USP39
2 |
PRPF4B binds USP39. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23602568
PRPF19 affects USP39
1 | 1
PRPF19 ubiquitinates USP39.
| 1
PRPF19 ubiquitinates USP39. 1 / 1
| 1
reach
"On the other hand, ubiquitination of PRP8 at the C-terminal by PRP19 was not as significant and PRP4B kinase and USP39 were not ubiquitinated by PRP19."
28088760
PRPF19 binds USP39.
1 |
PRPF19 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26344197
KAT8 affects USP39
| 1 1
KAT8 acetylates USP39. 2 / 2
| 1 1
sparser
"The results of this study demonstrated that USP39 can be acetylated by the histone acetyltransferase MYST1, which is required for its proteasome-mediated degradation by Von Hippel-Lindau protein."
32711345
reach
"The results of this study demonstrated that USP39 can be acetylated by the histone acetyltransferase MYST1, which is required for its proteasome mediated degradation by Von Hippel-Lindau protein."
32711345
FOXM1 affects USP39
| 2
USP39 binds FOXM1. 2 / 2
| 2
sparser
"The interaction between USP39 and FOXM1 was investigated using co-immunoprecipitation (co-IP) and in vitro deubiquitination analysis."
36119839
sparser
"In general, our research revealed the USP39-FOXM1 axis as a critical driver of breast cancer cell proliferation and provided a theoretical foundation for targeting the USP39-FOXM1 axis for pancreatic cancer treatment."
36119839
EGFR affects USP39
| 2
EGFR activates USP39. 2 / 2
| 2
reach
"EGFR is a downstream target of USP39."
26959883
reach
"To verify whether the regulatory effect of USP39 was EGFR specific, ectopic expression of USP39 were performed in PC-3 and DU145 cells, which showed that overexpressed USP39 upregulated EGFR mRNA and protein levels, indicating that EGFR is a downstream target of USP39."
26959883
Trimellitic anhydride increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
19042947
Tetrachloromethane increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
31150632
Sodium arsenite affects USP39
1 |
Sodium arsenite increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
29361514
Sodium arsenate affects USP39
1 |
Sodium arsenate increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
23922661
sparser
"Inhibition of USP39 by siRNA has downregulated FOXM1 and in turn led to tumor volume reduction in xenograft model of HCC ( xref )."
33680951
Short hairpin RNA affects USP39
| 1
Short hairpin RNA inhibits USP39. 1 / 1
| 1
sparser
"Therefore, the inhibition of USP39 by shRNA might be a potential therapeutic method in MTC."
26303214
ShRNA affects USP39
| 1
ShRNA inhibits USP39. 1 / 1
| 1
eidos
"C Global splicing efficiency analysis at 5 ' splicing site ( 5ss ) and 3 ' splicing site ( 3ss ) in A2780 cells with and without USP39 depletion by shRNA ."
33731694
Rev affects USP39
1 |
USP39 binds rev. 1 / 1
1 |
virhostnet
No evidence text available
22174317
Potential transcription affects USP39
| 1
Potential transcription activates USP39. 1 / 1
| 1
eidos
"We analyzed the USP39 promoter region to predict potential transcription factors that drive USP39 expression ."
33731694
Pirinixic acid affects USP39
1 |
Pirinixic acid decreases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
21318169
Perfluorooctane-1-sulfonic acid decreases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
26178269
Overexpression c-MYC affects USP39
| 1
Overexpression c-MYC activates USP39. 1 / 1
| 1
eidos
"As expected , overexpression of c-MYC significantly increased USP39 expression at both the RNA and protein level ."
33731694
Oncogene protein c-MYC affects USP39
| 1
Oncogene protein c-MYC activates USP39. 1 / 1
| 1
reach
"Importantly, USP39 was transcriptionally activated by the oncogene protein c-MYC in ovarian cancer cells."
33731694
Oncogene protein c-MYC ovarian cancer cells affects USP39
| 1
Oncogene protein c-MYC ovarian cancer cells activates USP39. 1 / 1
| 1
eidos
"Importantly , USP39 was transcriptionally activated by the oncogene protein c-MYC in ovarian cancer cells ."
33731694
Nimesulide affects USP39
1 |
Nimesulide increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
24136188
Nefazodone affects USP39
1 |
Nefazodone increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
24136188
MiR-370-3p affects USP39
| 1
MiR-370-3p inhibits USP39. 1 / 1
| 1
reach
"According to dual-luciferase reporter assay and RNA pull-down assay, miR-370-3p was identified to be targeted and sponged by circCLSPN, and further targeted and negatively regulated USP39."
34269180
MiR-133a affects USP39
| 1
MiR-133a activates USP39. 1 / 1
| 1
reach
"It has been reported that miR-133a inhibits cell progression by targeting USP39 in pancreatic cancer."
29805563
Methamphetamine affects USP39
1 |
Methamphetamine increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
29802913
Mercury(0) affects USP39
1 |
Mercury(0) increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
16823088
Lead atom affects USP39
1 |
Lead atom decreases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
19921347
Indometacin affects USP39
1 |
Indometacin increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
28628672
Hydroperoxide affects USP39
1 |
Hydroperoxide increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
26846883
Hsa-miR-193b-3p affects USP39
1 |
Hsa-miR-193b-3p decreases the amount of USP39. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20304954
Glyphosate affects USP39
1 |
Glyphosate increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
22467014
Gentamycin affects USP39
1 |
Gentamycin increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
22061828
Flutamide affects USP39
1 |
Flutamide increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
24136188
Dexamethasone affects USP39
1 |
Dexamethasone increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
28628672
Deoxynivalenol affects USP39
1 |
Deoxynivalenol dephosphorylates USP39. 1 / 1
1 |
ctd
No evidence text available
23352502
Carbon nanotube affects USP39
1 |
Carbon nanotube increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
25554681
Cadmium atom affects USP39
1 |
Cadmium atom decreases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
24067728
Biotin affects USP39
| 1
Biotin binds USP39. 1 / 1
| 1
reach
"Consistent with this, USP39 bound to biotin labeled HMGA2 in an RNA pull-down assay, indicating a direct interaction between USP39 and HMGA2."
33731694
Benzo[a]pyrene affects USP39
1 |
Benzo[a]pyrene increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
22228805
All-trans-retinoic acid decreases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
16604517
Acrylamide affects USP39
1 |
Acrylamide increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
28959563
Abrine affects USP39
1 |
Abrine increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
31054353
ZNHIT2 affects USP39
1 |
ZNHIT2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
28561026
ZC3H18 affects USP39
1 |
USP39 binds ZC3H18. 1 / 1
1 |
biogrid
No evidence text available
22939629
YP_009227196 affects USP39
1 |
USP39 binds YP_009227196. 1 / 1
1 |
virhostnet
No evidence text available
30037810
WWOX affects USP39
1 |
WWOX binds USP39. 1 / 1
1 |
biogrid
No evidence text available
24550385
Vehicle Emissions affects USP39
1 |
Vehicle Emissions demethylates USP39. 1 / 1
1 |
ctd
No evidence text available
25560391
VTN affects USP39
1 |
VTN binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
VEGFA affects USP39
| 1
VEGFA binds USP39. 1 / 1
| 1
sparser
"The interaction between USP39 and VEGF-A alternative splicing was assessed by affinity purification and mass spectrometry, co-immunoprecipitation and Western blot assays."
34544400
Ualcan databases affects USP39
| 1
Ualcan databases activates USP39. 1 / 1
| 1
eidos
"It was consistent with the observation in Ualcan databases , by which USP39 expression was significantly upregulated in advanced stages and grades of HCC patients ( Supplementary Figures 3A , B ) ."
33718205
USP9X affects USP7
| 1
USP10 binds USP7, USP9X, USP39, and FOXA1. 1 / 1
| 1
sparser
"To identify potential enzymes that could deubiquitinate FOXA1, we performed mass spectrometry analysis of FOXA1-associated proteins in LNCaP cells, which revealed multiple deubiquitinases, including USP7, USP39, USP10, and USP9X, that interact with FOXA1 (fig."
33827814
USP4 affects UBL
| 1
USP4 binds USP39 and UBL. 1 / 1
| 1
sparser
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [ xref , xref ], implying that USP39 might be deubiquitylating USP4."
28659380
USP4 affects UBL domain
| 1
USP4 binds USP39 and UBL domain. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 affects β-amyrin
| 1
USP39 activates β-amyrin. 1 / 1
| 1
reach
"Co-expression of tHMGR and SAD1 in about 460 N. benthamiana plants and cultivation for 5 days allowed successful isolation of 800 mg of β-amyrin with >98% purity."
34142684
USP39 affects volume
| 1
USP39 activates volume. 1 / 1
| 1
eidos
"USP39 depletion led to reduced tumor mass and volume ( Fig. 3B ) ."
33731694
USP39 affects tumorigenic potential
| 1
USP39 activates tumorigenic potential. 1 / 1
| 1
eidos
"USP39 knockdown inhibited the proliferation and colony formation of A549 and HCC827 cells and decreased tumorigenic potential in nude mice ."
33255748
USP39 affects tumorigenesis ovarian cancer nude mice xenografts
| 1
USP39 activates tumorigenesis ovarian cancer nude mice xenografts. 1 / 1
| 1
eidos
"USP39 promotes tumorigenesis and progression of ovarian cancer in nude mice xenografts ."
33731694
USP39 affects tumor growth glioma
| 1
USP39 activates tumor growth glioma. 1 / 1
| 1
eidos
"Besides , USP39 inhibits TAZ mRNA expression and promotes tumor growth in glioma [ 84 ] ."
| PMC
USP39 affects translation
| 1
USP39 activates translation. 1 / 1
| 1
reach
"In addition, USP39 overexpression could promote SRPK1 phosphorylation of SRSF1, while knockdown of USP39 worked oppositely, confirming that USP39 and SRPK1 play a role through direct binding rather than affecting their transcription or translation."
34544400
USP39 affects stability p53 protein
| 1
USP39 inhibits stability p53 protein. 1 / 1
| 1
eidos
"Furthermore , USP39 knockdown increased the stability of the p53 protein by prolonging its half-life ."
33255748
USP39 affects splicing
| 1
USP39 activates splicing. 1 / 1
| 1
eidos
"RNA-sequencing analysis revealed that USP39 depletion led to globally impaired splicing that is characterized by skipped exons and overrepresentation of introns and intergenic regions ."
33731694
USP39 affects splicing exon-exon minigene transcripts
| 1
USP39 activates splicing exon-exon minigene transcripts. 1 / 1
| 1
eidos
"USP39 depletion markedly reduced the splicing of the three exon-exon minigene transcripts and increased splicing of the exon-intron minigene transcript ( Fig. 7F ) ."
33731694
reach
"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
36707504
USP39 affects rev
1 |
USP39 binds rev. 1 / 1
1 |
virhostnet
No evidence text available
22174317
USP39 affects proliferation- related genes
| 1
USP39 activates proliferation- related genes. 1 / 1
| 1
reach
"The co-concurrence analysis suggested that USP39 might promote HCC by regulating cell-cycle- and proliferation- related genes."
33718205
USP39 affects pre-mRNA splicing efficiency
| 1
USP39 activates pre-mRNA splicing efficiency. 1 / 1
| 1
eidos
"Previously , USP39 depletion was found to cause a significant reduction in pre-mRNA splicing efficiency in colon cancer and glioma25 ,30 ."
33731694
USP39 affects p53-responsive transcriptional reporter
| 1
USP39 inhibits p53-responsive transcriptional reporter. 1 / 1
| 1
eidos
"In addition , by employing a double luciferase reporter system assay , we found that depletion of USP39 enhances p53-responsive transcriptional reporter activity ."
33255748
USP39 affects p53 pathway
| 1
USP39 inhibits p53 pathway. 1 / 1
| 1
eidos
"Meanwhile , we found that USP39 knockdown also activates the p53 pathway , upregulation of p53 , p-p53 ( S15 ) , p21 and BAX in HCC827 cells ( Figure S2 ) ."
33255748
USP39 affects overall survival mice
| 1
USP39 inhibits overall survival mice. 1 / 1
| 1
eidos
"USP39 promoted the invasion of glioma cells in vivo and reduced the overall survival of the mice ."
33811456
USP39 affects ovarian cancer cells
| 1
USP39 activates ovarian cancer cells. 1 / 1
| 1
eidos
"The results of these assays indicated that overexpression of USP39 promoted , whereas knockdown of USP39 prevented , the proliferation of ovarian cancer cells ."
33731694
USP39 affects non-homologous end-joining repair
| 1
USP39 activates non-homologous end-joining repair. 1 / 1
| 1
eidos
"USP39 promotes non-homologous end-joining repair by poly ( ADP-ribose ) - induced liquid demixing ."
34614178
USP39 affects migration
| 1
USP39 activates migration. 1 / 1
| 1
eidos
"Knockdown of USP39 in U251 and U87 cell lines significantly inhibited their migration and invasion in vitro ."
33811456
USP39 affects migration invasion cells
| 1
USP39 activates migration invasion cells. 1 / 1
| 1
eidos
"Moreover , USP39 knockdown significantly inhibited migration and invasion of A549 and HCC827 cells , also via activation of the p53 pathway , and downregulation of MMP2 and MMP9 ."
33255748
USP39 affects metastasis lung cancer cells
| 1
USP39 activates metastasis lung cancer cells. 1 / 1
| 1
eidos
"Together , these data demonstrate that USP39 knockdown inhibits the metastasis of lung cancer cells in vivo and in vitro ."
33255748
USP39 affects metabolic process
| 1
USP39 activates metabolic process. 1 / 1
| 1
reach
"In yeast, the ABH1 homolog CBP80 and the SAD1 homolog Lsm5 are active components of the spliceosome and mediate various steps of RNA metabolism [47], but these two proteins do not seem to interact dir[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12972047
USP39 affects malignancy ovarian cancer cells
| 1
USP39 activates malignancy ovarian cancer cells. 1 / 1
| 1
eidos
"In particular , USP39 facilitates efficient splicing of HMGA2 and thereby increases the malignancy of ovarian cancer cells ."
33731694
USP39 affects mRNA processing
| 1
USP39 activates mRNA processing. 1 / 1
| 1
eidos
"Altogether , our data shows that USP39 induces mRNA maturation and elevates the expression of ADAM9 in glioma cells and may thus be considered as potential target for treating patients with glioma ."
33811456
USP39 affects invasion glioma cells
| 1
USP39 activates invasion glioma cells. 1 / 1
| 1
eidos
"USP39 promoted the invasion of glioma cells in vivo and reduced the overall survival of the mice ."
33811456
USP39 affects human glioma cells migration
| 1
USP39 activates human glioma cells migration. 1 / 1
| 1
eidos
"Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation ."
33811456
USP39 affects growth xenograft tumors
| 1
USP39 activates growth xenograft tumors. 1 / 1
| 1
eidos
"USP39 increases proliferation / invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice We next explored whether USP39 was functionally relevant for ovarian progression ."
33731694
USP39 affects growth subcutaneous tumor colon cancer cells
| 1
USP39 activates growth subcutaneous tumor colon cancer cells. 1 / 1
| 1
eidos
"Whilst overexpression of USP39 was detected in human colon cancer tissues and cell lines , USP39 knockdown was observed to inhibit the growth and subcutaneous tumor formation of colon cancer cells ."
33634905
USP39 affects glioma25
| 1
USP39 activates glioma25. 1 / 1
| 1
eidos
"Previously , USP39 depletion was found to cause a significant reduction in pre-mRNA splicing efficiency in colon cancer and glioma25 ,30 ."
33731694
USP39 affects exonic reads
| 1
USP39 activates exonic reads. 1 / 1
| 1
eidos
"Analysis of the reads mapping distribution revealed that USP39 depletion significantly reduced the proportion of exonic reads , whereas it increased the proportion of intergenic and intronic reads ( Fig. 6B ) , indicating that there is a widespread impairment in pre-mRNA splicing upon the loss of USP39 ."
33731694
USP39 affects epithelial-mesenchymal transition EMT ovarian cancer cells
| 1
USP39 activates epithelial-mesenchymal transition EMT ovarian cancer cells. 1 / 1
| 1
eidos
"USP39 promotes proliferation / invasion and epithelial-mesenchymal transition ( EMT ) of ovarian cancer cells ."
33731694
USP39 affects colony
| 1
USP39 activates colony. 1 / 1
| 1
eidos
"USP39 knockdown has been found to inhibit the proliferation and colony formation through downregulating the transcription factor Forkhead Box M1 ( 29 ) ."
33718205
USP39 affects colony A549 cells
| 1
USP39 activates colony A549 cells. 1 / 1
| 1
eidos
"USP39 knockdown inhibited the proliferation and colony formation of A549 and HCC827 cells and decreased tumorigenic potential in nude mice ."
33255748
USP39 affects clonogenicity
| 1
USP39 activates clonogenicity. 1 / 1
| 1
eidos
"We then performed a clonogenic assay and found that USP39 dramatically promoted the clonogenic capacity , whereas USP39 inhibition led to reduced clonogenicity ( Fig. 2A ) ."
33731694
USP39 affects clonogenic capacity
| 1
USP39 activates clonogenic capacity. 1 / 1
| 1
eidos
"We then performed a clonogenic assay and found that USP39 dramatically promoted the clonogenic capacity , whereas USP39 inhibition led to reduced clonogenicity ( Fig. 2A ) ."
33731694
USP39 affects cisplatin-induced apoptosis HCT116 cells
| 1
USP39 inhibits cisplatin-induced apoptosis HCT116 cells. 1 / 1
| 1
eidos
"Depletion of USP39 enhances the cisplatin-induced apoptosis in HCT116 cells ."
34822033
reach
"A previous study indicated that USP39 silencing induced defective chromosome segregation and cytokinesis in U2OS cells, indicating USP39 is critical in the regulation of mitosis."
29556295
USP39 affects cell-cycle-
| 1
USP39 activates cell-cycle-. 1 / 1
| 1
reach
"The co-concurrence analysis suggested that USP39 might promote HCC by regulating cell-cycle- and proliferation- related genes."
33718205
USP39 affects cell
| 1
USP39 activates cell. 1 / 1
| 1
eidos
"Here , we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin beta-catenin , a key molecular of Wnt / beta-catenin signaling pathway whose abnormal expression or activation results in several tumors , following its co-localization with USP39 ."
36707504
USP39 affects cell migration invasion USP39KD cells
| 1
USP39 activates cell migration invasion USP39KD cells. 1 / 1
| 1
eidos
"As shown in Figure 5A-F , USP39 knockdown reduced the cell migration and invasion of both USP39KD cells in comparison to the control cells ( * p < 0.05 , * * p < 0.01 , * * * * p < 0.0001 ) ."
33255748
USP39 affects cell migration A549 HCC827 cells
| 1
USP39 activates cell migration A549 HCC827 cells. 1 / 1
| 1
eidos
"We further observed that USP39 downregulation inhibits the cell proliferation and migration of A549 and HCC827 cells ."
33255748
USP39 affects cell growth aerobic glycolysis oral cancer
| 1
USP39 inhibits cell growth aerobic glycolysis oral cancer. 1 / 1
| 1
eidos
"Elevated Sad1 and UNC84 Domain Containing 2 ( SUN2 ) level inhibits cell growth and aerobic glycolysis in oral cancer through reducing the expressions of glucose transporter 1 ( GLUT1 ) and lactate dehydrogenase A ( LDHA ) Background / purpose Oral cancer is a malignant tumor accompanied by high morbidity , mortality , and poor prognosis ."
33384835
USP39 affects cell death
| 1
USP39 activates cell death. 1 / 1
| 1
reach
"Knockdown of SF3B1, PRPF8, UBL5 and USP39 increased cell death in all cSCC cell lines."
29796170
USP39 affects biotin
| 1
Biotin binds USP39. 1 / 1
| 1
reach
"Consistent with this, USP39 bound to biotin labeled HMGA2 in an RNA pull-down assay, indicating a direct interaction between USP39 and HMGA2."
33731694
USP39 affects apoptosis induced cisplatin
| 1
USP39 inhibits apoptosis induced cisplatin. 1 / 1
| 1
eidos
"Furthermore , we demonstrate that USP39 depletion promotes apoptosis induced by cisplatin , which is related with the induction of oxidative stress and DNA damage response ."
34822033
USP39 affects antitumor cisplatin colon cancer cells dependent p53
| 1
USP39 inhibits antitumor cisplatin colon cancer cells dependent p53. 1 / 1
| 1
eidos
"USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53 ."
34822033
USP39 affects activation p53 pathway
| 1
USP39 inhibits activation p53 pathway. 1 / 1
| 1
eidos
"Most importantly , the depletion of USP39 was found to result in the activation of the p53 pathway and to promote the expression of the p53 targets p21 , CDC2 , cyclinB1 , MMP2 and MMP9 ."
33255748
USP39 affects accumulation p53
| 1
USP39 inhibits accumulation p53. 1 / 1
| 1
eidos
"Altogether , these results suggest that USP39 knockdown causes a significant accumulation of p53 via regulating both transcriptional levels and post-translational modifications of p53 ."
33255748
USP39 affects abnormal cell cycle distribution
| 1
USP39 inhibits abnormal cell cycle distribution. 1 / 1
| 1
eidos
"First , we observed that depletion of USP39 contributes to abnormal cell cycle distribution by inducing cell cycle arrest at G2 / M. Moreover , the underlying mechanism of action of USP39 is partly dependent on activation of the p53 pathway , upregulation of p53 and p21 , and downregulation of CDC2 and CyclinB1 [ 29 ] in A549 cells ."
33255748
USP39 affects ZNHIT2
1 |
ZNHIT2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
28561026
USP39 affects ZC3H18
1 |
USP39 binds ZC3H18. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects YP_009227196
1 |
USP39 binds YP_009227196. 1 / 1
1 |
virhostnet
No evidence text available
30037810
USP39 affects Wnt/β-catenin
| 1
USP39 activates Wnt/β-catenin. 1 / 1
| 1
reach
"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
36707504
USP39 affects WWOX
1 |
WWOX binds USP39. 1 / 1
1 |
biogrid
No evidence text available
24550385
USP39 affects VTN
1 |
VTN binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects VEGF-A165b
| 1
USP39 activates VEGF-A165b. 1 / 1
| 1
reach
"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1."
34544400
USP39 affects VEGF
| 1
USP39 increases the amount of VEGF. 1 / 1
| 1
reach
"USP39 knockdown significantly reduced the expression level of VEGF 165, but had no significant effect on overall VEGF-A (Additional file 1: Figure S1)."
34544400
USP39 affects USP9X
| 1
USP10 binds USP7, USP9X, USP39, and FOXA1. 1 / 1
| 1
sparser
"To identify potential enzymes that could deubiquitinate FOXA1, we performed mass spectrometry analysis of FOXA1-associated proteins in LNCaP cells, which revealed multiple deubiquitinases, including USP7, USP39, USP10, and USP9X, that interact with FOXA1 (fig."
33827814
USP39 affects USP39
| 1
USP39 activates USP39. 1 / 1
| 1
reach
"Indeed, silencing USP39 expression markedly inhibited the proliferation and metastasis of HCC cells in vitro and in vivo experiments, indicating the potential carcinogenic effect of USP39 in HCC development."
33649471
USP39 affects USP36
| 1
USP36 binds USP39. 1 / 1
| 1
sparser
"Most USPs are abnormally expressed in HCC, among which USP36 and USP39 are most closely associated with HCC prognosis."
35748266
USP39 affects USP13
| 1
STAT1 binds USP13, USP39, and BRCC36. 1 / 1
| 1
sparser
"For example, the three deubiquitinating enzymes BRCC36, USP13, and USP39 interact with STAT1 and decrease the K63-, K48- and K6-linked polyubiquitin chains of STAT1 respectively (110, 115, 118)."
34707613
USP39 affects USP12
1 |
USP39 binds USP12. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects USP10
| 1
USP10 binds USP7, USP9X, USP39, and FOXA1. 1 / 1
| 1
sparser
"To identify potential enzymes that could deubiquitinate FOXA1, we performed mass spectrometry analysis of FOXA1-associated proteins in LNCaP cells, which revealed multiple deubiquitinases, including USP7, USP39, USP10, and USP9X, that interact with FOXA1 (fig."
33827814
USP39 affects UBL
| 1
USP4 binds USP39 and UBL. 1 / 1
| 1
sparser
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [ xref , xref ], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 affects UBL domain
| 1
USP4 binds USP39 and UBL domain. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 affects TXNL4A
1 |
USP39 binds TXNL4A. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects TSR2
1 |
USP39 binds TSR2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects TRMT10C
1 |
USP39 binds TRMT10C. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects TRIM8
1 |
TRIM8 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP39 affects TRIM55
1 |
TRIM55 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects TRIM5
1 |
TRIM5 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP39 affects TRIM39
1 |
TRIM39 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP39 affects TRAF6
1 |
TRAF6 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
USP39 affects TPBG
1 |
TPBG binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects TAZ
| 1
USP39 activates TAZ. 1 / 1
| 1
reach
"Finally, loss of USP39 decreased TAZ pre-mRNA splicing efficiency in glioma cells in vitro, which led to reduced levels of TAZ protein."
31332287
USP39 affects TAZ mRNA
| 1
USP39 inhibits TAZ mRNA. 1 / 1
| 1
eidos
"Besides , USP39 inhibits TAZ mRNA expression and promotes tumor growth in glioma [ 84 ] ."
| PMC
USP39 affects Spliceosomes
| 1
USP39 activates Spliceosomes. 1 / 1
| 1
eidos
"To test whether USP39 modulate spliceosome activity via SF3B1 , we measured phosphorylated SF3B1 in ovarian cancer cells with USP39 overexpression or knockdown ."
33731694
USP39 affects SUPT16H
1 |
SUPT16H binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SUMOylation specific protein
| 1
USP39 activates SUMOylation specific protein. 1 / 1
| 1
reach
"Wen et al. [XREF_BIBR] have reported that USP39 is a target of SUMOylation specific protein (SENP) in the proliferation of PCa cells."
26959883
USP39 affects STAT1
| 1
STAT1 binds USP13, USP39, and BRCC36. 1 / 1
| 1
sparser
"For example, the three deubiquitinating enzymes BRCC36, USP13, and USP39 interact with STAT1 and decrease the K63-, K48- and K6-linked polyubiquitin chains of STAT1 respectively (110, 115, 118)."
34707613
USP39 affects STAT
| 1
USP39 activates STAT. 1 / 1
| 1
reach
"Mechanistically, USP39 does not affect the production of type I IFN but significantly promotes JAK and STAT downstream of type I signaling by enhancing IFN stimulated response elements promoter activity and expression of IFN stimulated genes."
33127822
USP39 affects SRSF7
1 |
SRSF7 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SRSF5
1 |
SRSF5 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SRSF3
1 |
SRSF3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SRSF2
| 1
SRSF2 binds USP39. 1 / 1
| 1
sparser
"USP39 interacts with several spliceosome components and colocalizes with SC35 in nuclear speckles."
33731694
USP39 affects SRSF11
1 |
SRSF11 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SRSF10
1 |
SRSF10 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SRPK2
1 |
SRPK2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26167880
USP39 affects SON
1 |
SON binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SNRNP40
1 |
USP39 binds SNRNP40. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects SNRNP27
1 |
USP39 binds SNRNP27. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects SNRNP200
1 |
USP39 binds SNRNP200. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects SF3B6
1 |
USP39 binds SF3B6. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SF3B1
1 |
SF3B1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SF3A1
1 |
SF3A1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SCARNA22
1 |
USP39 binds SCARNA22. 1 / 1
1 |
biogrid
No evidence text available
22751105
USP39 affects SART3
1 |
SART3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects SART1
1 |
SART1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects SAG1
| 1
USP39 binds SAG1. 1 / 1
| 1
reach
"The interaction is strong and may indeed be irreversible, since the Sag1-Sad1 complex is proteolytically shed into the medium [23] ."
35163034
USP39 affects SAFB
1 |
SAFB binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects SAE1
1 |
USP39 binds SAE1. 1 / 1
1 |
biogrid
No evidence text available
25027693
USP39 affects RUVBL2
1 |
RUVBL2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects RRP8
1 |
USP39 binds RRP8. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects RPL22L1
1 |
USP39 binds RPL22L1. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects RP23-384C18.4
1 |
USP39 binds RP23-384C18.4. 1 / 1
1 |
biogrid
No evidence text available
20360068
USP39 affects RNU6ATAC
1 |
USP39 binds RNU6ATAC. 1 / 1
1 |
biogrid
No evidence text available
11971955
USP39 affects RNU4ATAC
1 |
biogrid
No evidence text available
11971955
USP39 affects RCC
| 1
USP39 inhibits RCC. 1 / 1
| 1
reach
"Depletion of USP39 by siRNA significantly suppressed cell growth and decreased invasive capacity of RCC cells."
29328477
USP39 affects RBM39
1 |
RBM39 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects RAC
| 1
USP39 phosphorylates RAC. 1 / 1
| 1
sparser
"Mechanistic analyses also demonstrated that USP39 induced the phosphorylation of extracellular signal‑regulated kinase and AKT and increased the expression of epidermal growth factor receptor and cyclin B1."
31180526
USP39 affects PTEN
1 |
USP39 binds PTEN. 1 / 1
1 |
biogrid
No evidence text available
24270891
USP39 affects PRPF8
1 |
PRPF8 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects PRPF6
1 |
PRPF6 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects PRPF31
1 |
PRPF31 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects PRPF3
1 |
PRPF3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects PRPF19
1 |
PRPF19 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects PCNA
1 |
USP39 binds PCNA. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects PC
| 1
USP39 inhibits PC. 1 / 1
| 1
reach
"Furthermore, high USP39 expression was observed in PC cell lines and ectopic expression of USP39 significantly enhanced invitro cell proliferation and promoted invivo tumor growth, whereas silencing USP39 suppressed growth of PC cells."
28286270
USP39 affects PA2G4
1 |
USP39 binds PA2G4. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects OBSL1
1 |
USP39 binds OBSL1. 1 / 1
1 |
biogrid
No evidence text available
24711643
USP39 affects NTRK1
1 |
USP39 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
USP39 affects NSUN2
1 |
USP39 binds NSUN2. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects NOC3L
1 |
USP39 binds NOC3L. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects NCSTN
1 |
NCSTN binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects NCL
1 |
USP39 binds NCL. 1 / 1
1 |
biogrid
No evidence text available
27049334
USP39 affects NCAPD3
1 |
USP39 binds NCAPD3. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects Metastatic Cells Vitro potential contribution USP39 metastatic capacity A549 HCC827 cells performed Matrigel non-coated Transwell migration coated Transwell invasion assays
| 1
USP39 activates Metastatic Cells Vitro potential contribution USP39 metastatic capacity A549 HCC827 cells performed Matrigel non-coated Transwell migration coated Transwell invasion assays. 1 / 1
| 1
eidos
"Knockdown of USP39 Inhibits Metastatic of Lung Cancer Cells In Vivo and In Vitro To test the potential contribution of USP39 to the metastatic capacity of A549 and HCC827 cells , in vitro , we performed Matrigel non-coated Transwell migration and Matrigel coated Transwell invasion assays ."
33255748
USP39 affects MTOR
| 1
USP39 inhibits MTOR. 1 / 1
| 1
reach
"Moreover, depletion of USP39 blocked activation of Akt, mTOR, p53, and PARP signaling pathways."
27629785
USP39 affects MRM3
1 |
MRM3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects MMS19
1 |
MMS19 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22678362
USP39 affects MEPCE
1 |
USP39 binds MEPCE. 1 / 1
1 |
biogrid
No evidence text available
17643375
USP39 affects LSM8
1 |
USP39 binds LSM8. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects LGALS9
1 |
USP39 binds LGALS9. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects K63
| 1
USP39 inhibits K63. 1 / 1
| 1
eidos
"For example , the three deubiquitinating enzymes BRCC36 , USP13 , and USP39 interact with STAT1 and decrease the K63 - , K48 - and K6-linked polyubiquitin chains of STAT1 respectively ( 110 , 115 , 118 ) ."
34707613
USP39 affects JAK
| 1
USP39 activates JAK. 1 / 1
| 1
reach
"Mechanistically, USP39 does not affect the production of type I IFN but significantly promotes JAK and STAT downstream of type I signaling by enhancing IFN stimulated response elements promoter activity and expression of IFN stimulated genes."
33127822
USP39 affects Integrins
| 1
USP39 decreases the amount of Integrins. 1 / 1
| 1
reach
"Further on, USP39 induced ADAM9 mRNA maturation and decreased the expression of integrin beta1."
33811456
USP39 affects ITGB1
| 1
USP39 inhibits ITGB1. 1 / 1
| 1
eidos
"Further on , USP39 induced ADAM9 mRNA maturation and decreased the expression of integrin beta1 ."
33811456
USP39 affects IFN-mediated antiviral responses
| 1
USP39 activates IFN-mediated antiviral responses. 1 / 1
| 1
eidos
"Intriguingly , USP39 promotes IFN-mediated antiviral responses by decreasing K6-linked but not canonical K48-linked polyubiquitination of STAT1 for degradation ( 118 ) , eventhough K6-linked ubiquitin chains are often related to DNA damage instead of protein degradation ( 142 ) ."
34707613
USP39 affects Half-Life
| 1
USP39 activates Half-Life. 1 / 1
| 1
eidos
"We observe that USP39 stabilizes SP1 protein and prolongs its half-life by promoting its deubiquitylation pathway ."
34197957
USP39 affects HSPH1
1 |
HSPH1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects HSPA4
1 |
USP39 binds HSPA4. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects HNRNPU
1 |
USP39 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects HNRNPC
1 |
USP39 binds HNRNPC. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects HIV1gp6
1 |
USP39 binds HIV1gp6. 1 / 1
1 |
biogrid
No evidence text available
22174317
USP39 affects GTF3C1
1 |
USP39 binds GTF3C1. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects GAR1
1 |
GAR1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects FOXA1
| 1
USP10 binds USP7, USP9X, USP39, and FOXA1. 1 / 1
| 1
sparser
"To identify potential enzymes that could deubiquitinate FOXA1, we performed mass spectrometry analysis of FOXA1-associated proteins in LNCaP cells, which revealed multiple deubiquitinases, including USP7, USP39, USP10, and USP9X, that interact with FOXA1 (fig."
33827814
USP39 affects FN1
1 |
USP39 binds FN1. 1 / 1
1 |
biogrid
No evidence text available
19738201
USP39 activates Esophageal Squamous Cell Carcinoma. 1 / 1
| 1
reach
"The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor."
35627203
USP39 affects EFTUD2
1 |
USP39 binds EFTUD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects EAPP
1 |
EAPP binds USP39. 1 / 1
1 |
biogrid
No evidence text available
28561026
USP39 binds DLGAP1 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Other non-coding RNAs, i.e.,: miR-34a, DLGAP1-AS1, USP39, and RNA5SP479, were highlighted by network analyses to have potential in the pathogenesis of UTUC."
35659483
reach
"The depletion of USP39 has been found to cause activation of the p53 signaling pathway, an important regulatory mechanism in cell cycle and DNA replication, by stabilizing the p53 target p21 in multiple kinds of cancer cell lines [23, 26, 27]."
34987596
USP39 affects DLGAP1
| 1
USP39 binds DLGAP1 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Other non-coding RNAs, i.e.,: miR-34a, DLGAP1-AS1, USP39, and RNA5SP479, were highlighted by network analyses to have potential in the pathogenesis of UTUC."
35659483
USP39 affects DHX9
1 |
USP39 binds DHX9. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects DHX38
1 |
DHX38 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects DDX24
1 |
DDX24 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects DDX23
1 |
DDX23 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects CyclinB1
| 1
USP39 inhibits CyclinB1. 1 / 1
| 1
reach
"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
33255748
USP39 affects Cyclin
| 1
USP39 decreases the amount of Cyclin. 1 / 1
| 1
reach
"Knockdown of USP39 inhibits VSMC proliferation and the expression of cyclin D1 and CDK4."
28447728
USP39 affects Colonic Neoplasms
| 1
USP39 activates Colonic Neoplasms. 1 / 1
| 1
eidos
"Previously , USP39 depletion was found to cause a significant reduction in pre-mRNA splicing efficiency in colon cancer and glioma25 ,30 ."
33731694
USP39 affects Cell Survival
| 1
USP39 activates Cell Survival. 1 / 1
| 1
reach
"Overexpression of USP39 significantly increased the invasion ability and cell survival curve ( p < 0.05)."
36046375
USP39 activates Carcinoma, Renal Cell. 1 / 1
| 1
reach
"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
34544400
USP39 affects CYCD1-1
| 1
USP39 decreases the amount of CYCD1-1. 1 / 1
| 1
reach
"Knockdown of USP39 in VSMCs inhibited cyclinD1 and CDK4 protein expression compared with transfection with control siRNA (XREF_FIG), which are essential proteins for G1/S phase transformation."
28447728
USP39 affects CUL7
1 |
USP39 binds CUL7. 1 / 1
1 |
biogrid
No evidence text available
24711643
USP39 affects CTNNB1
| 1
USP39 increases the amount of CTNNB1. 1 / 1
| 1
reach
"In summary, our data reveal a novel mechanism in the progress of HCC that USP39 promotes the proliferation and migration of HCC through increasing β-catenin level via both direct deubiquitination and reducing TRIM26 pre-mRNA maturation and splicing, which may provide a new idea and target for clinical treatment of HCC."
36707504
USP39 affects CSNK1E
1 |
USP39 binds CSNK1E. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects COPRS
1 |
USP39 binds COPRS. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP39 affects CHEK2
| 1
USP39 deubiquitinates CHEK2. 1 / 1
| 1
reach
"Mechanistically, USP39 deubiquitinates and stabilizes CHK2, which in turn enhances CHK2 stability."
30771428
USP39 affects CETN2
1 |
CETN2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP39 affects CDKN1B
| 1
CDKN1A binds CDKN1B, USP39, and BAX. 1 / 1
| 1
sparser
"In addition, USP39 silencing was associated with the increased expressions of p21, p27, and Bax."
27456357
USP39 affects CDK2
| 1
USP39 inhibits CDK2. 1 / 1
| 1
reach
"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
33255748
USP39 affects CDC5L
1 |
CDC5L binds USP39. 1 / 1
1 |
biogrid
No evidence text available
20467437
USP39 affects CDC2 cyclinB1
| 1
USP39 activates CDC2 cyclinB1. 1 / 1
| 1
eidos
"Additionally , USP39 knockdown led to downregulation of CDC2 , cyclinB1 , MMP2 and MMP9 through activating the p53 pathway ( Figure 6A ) ."
33255748
USP39 affects CCNA2
| 1
USP39 inhibits CCNA2. 1 / 1
| 1
reach
"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
33255748
USP39 affects CCDC8
1 |
USP39 binds CCDC8. 1 / 1
1 |
biogrid
No evidence text available
24711643
USP39 affects CAND1
1 |
USP39 binds CAND1. 1 / 1
1 |
biogrid
No evidence text available
21145461
USP39 affects BRCC36
| 1
STAT1 binds USP13, USP39, and BRCC36. 1 / 1
| 1
sparser
"For example, the three deubiquitinating enzymes BRCC36, USP13, and USP39 interact with STAT1 and decrease the K63-, K48- and K6-linked polyubiquitin chains of STAT1 respectively (110, 115, 118)."
34707613
USP39 affects AURKB
1 |
USP39 deubiquitinates AURKB. 1 / 1
1 |
ubibrowser
"USP39 deubiquitinates aurora B kinase maintaining spindle assembly checkpoint integrity [103] while USP44 stabilizes Mad2/Cdc20 complex inhibiting premature activation of the APC/CCdh1?complex"
25121098
USP39 affects ARF1
1 |
USP39 binds ARF1. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects APP
1 |
USP39 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
USP39 affects APEH
1 |
USP39 binds APEH. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects ADARB1
1 |
USP39 binds ADARB1. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP39 affects ADAM9 mRNA maturation
| 1
USP39 activates ADAM9 mRNA maturation. 1 / 1
| 1
eidos
"Further on , USP39 induced ADAM9 mRNA maturation and decreased the expression of integrin beta1 ."
33811456
USP39 affects ADAM9 cells
| 1
USP39 activates ADAM9 cells. 1 / 1
| 1
eidos
"Altogether , our data shows that USP39 induces mRNA maturation and elevates the expression of ADAM9 in glioma cells and may thus be considered as potential target for treating patients with glioma ."
33811456
USP39 affects ACVR1
1 |
ACVR1 binds USP39. 1 / 1
1 |
hprd
No evidence text available
15761153
USP36 affects USP39
| 1
USP36 binds USP39. 1 / 1
| 1
sparser
"Most USPs are abnormally expressed in HCC, among which USP36 and USP39 are most closely associated with HCC prognosis."
35748266
USP13 affects USP39
| 1
STAT1 binds USP13, USP39, and BRCC36. 1 / 1
| 1
sparser
"For example, the three deubiquitinating enzymes BRCC36, USP13, and USP39 interact with STAT1 and decrease the K63-, K48- and K6-linked polyubiquitin chains of STAT1 respectively (110, 115, 118)."
34707613
USP12 affects USP39
1 |
USP39 binds USP12. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP10 affects USP9X
| 1
USP10 binds USP7, USP9X, USP39, and FOXA1. 1 / 1
| 1
sparser
"To identify potential enzymes that could deubiquitinate FOXA1, we performed mass spectrometry analysis of FOXA1-associated proteins in LNCaP cells, which revealed multiple deubiquitinases, including USP7, USP39, USP10, and USP9X, that interact with FOXA1 (fig."
33827814
UBL affects USP4
| 1
USP4 binds USP39 and UBL. 1 / 1
| 1
sparser
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [ xref , xref ], implying that USP39 might be deubiquitylating USP4."
28659380
UBL domain affects USP4
| 1
USP4 binds USP39 and UBL domain. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
TXNL4A affects USP39
1 |
USP39 binds TXNL4A. 1 / 1
1 |
biogrid
No evidence text available
19615732
TSR2 affects USP39
1 |
USP39 binds TSR2. 1 / 1
1 |
biogrid
No evidence text available
19615732
TRMT10C affects USP39
1 |
USP39 binds TRMT10C. 1 / 1
1 |
biogrid
No evidence text available
19615732
TRIM8 affects USP39
1 |
TRIM8 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM55 affects USP39
1 |
TRIM55 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
TRIM5 affects USP39
1 |
TRIM5 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRIM39 affects USP39
1 |
TRIM39 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
TRAF6 affects USP39
1 |
TRAF6 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
23105109
TPBG affects USP39
1 |
TPBG binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
Surface-Active Agents increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
22467014
SUPT16H affects USP39
1 |
SUPT16H binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
STAT1 affects USP39
| 1
STAT1 binds USP13, USP39, and BRCC36. 1 / 1
| 1
sparser
"For example, the three deubiquitinating enzymes BRCC36, USP13, and USP39 interact with STAT1 and decrease the K63-, K48- and K6-linked polyubiquitin chains of STAT1 respectively (110, 115, 118)."
34707613
SRSF7 affects USP39
1 |
SRSF7 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRSF5 affects USP39
1 |
SRSF5 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRSF3 affects USP39
1 |
SRSF3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRSF2 affects USP39
| 1
SRSF2 binds USP39. 1 / 1
| 1
sparser
"USP39 interacts with several spliceosome components and colocalizes with SC35 in nuclear speckles."
33731694
SRSF11 affects USP39
1 |
SRSF11 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRSF10 affects USP39
1 |
SRSF10 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SRPK2 affects USP39
1 |
SRPK2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26167880
SP1 affects USP39
1 |
SP1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
20195357
SON affects USP39
1 |
SON binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SNRNP40 affects USP39
1 |
USP39 binds SNRNP40. 1 / 1
1 |
biogrid
No evidence text available
19615732
SNRNP27 affects USP39
1 |
USP39 binds SNRNP27. 1 / 1
1 |
biogrid
No evidence text available
19615732
SNRNP200 affects USP39
1 |
USP39 binds SNRNP200. 1 / 1
1 |
biogrid
No evidence text available
19615732
SF3B6 affects USP39
1 |
USP39 binds SF3B6. 1 / 1
1 |
biogrid
No evidence text available
22939629
SF3B1 affects USP39
1 |
SF3B1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SF3A1 affects USP39
1 |
SF3A1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SCARNA22 affects USP39
1 |
USP39 binds SCARNA22. 1 / 1
1 |
biogrid
No evidence text available
22751105
SART3 affects USP39
1 |
SART3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
SART1 affects USP39
1 |
SART1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
SAG1 affects USP39
| 1
USP39 binds SAG1. 1 / 1
| 1
reach
"The interaction is strong and may indeed be irreversible, since the Sag1-Sad1 complex is proteolytically shed into the medium [23] ."
35163034
SAFB affects USP39
1 |
SAFB binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
SAE1 affects USP39
1 |
USP39 binds SAE1. 1 / 1
1 |
biogrid
No evidence text available
25027693
RUVBL2 affects USP39
1 |
RUVBL2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26344197
RRP8 affects USP39
1 |
USP39 binds RRP8. 1 / 1
1 |
biogrid
No evidence text available
19615732
RPL22L1 affects USP39
1 |
USP39 binds RPL22L1. 1 / 1
1 |
biogrid
No evidence text available
19615732
RP23-384C18.4 affects USP39
1 |
USP39 binds RP23-384C18.4. 1 / 1
1 |
biogrid
No evidence text available
20360068
RNU6ATAC affects USP39
1 |
USP39 binds RNU6ATAC. 1 / 1
1 |
biogrid
No evidence text available
11971955
RNU4ATAC affects USP39
1 |
biogrid
No evidence text available
11971955
RBM39 affects USP39
1 |
RBM39 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
Plant Extracts affects USP39
1 |
Plant Extracts increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
23557933
PTEN affects USP39
1 |
USP39 binds PTEN. 1 / 1
1 |
biogrid
No evidence text available
24270891
PRPF8 affects USP39
1 |
PRPF8 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
PRPF6 affects USP39
1 |
PRPF6 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
PRPF31 affects USP39
1 |
PRPF31 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
PRPF3 affects USP39
1 |
PRPF3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
PRH2 affects USP39
| 1
PRH2 activates USP39. 1 / 1
| 1
sparser
"Importantly, USP39 was transcriptionally activated by the oncogene protein c-MYC in ovarian cancer cells."
33731694
POMC affects USP39
| 1
POMC activates mutated USP39. 1 / 1
| 1
reach
"Furthermore, injection of mRNA encoding wild-type usp39 rescued the mutant phenotype (XREF_TABLE), indicating that pituitary pomc upregulation in usp39 mutants results from the nonsense mutation in zebrafish usp39."
21249182
PCNA affects USP39
1 |
USP39 binds PCNA. 1 / 1
1 |
biogrid
No evidence text available
26344197
PAX4 affects USP39
1 |
PAX4 decreases the amount of USP39. 1 / 1
1 |
biopax:msigdb
No evidence text available
PA2G4 affects USP39
1 |
USP39 binds PA2G4. 1 / 1
1 |
biogrid
No evidence text available
19615732
OBSL1 affects USP39
1 |
USP39 binds OBSL1. 1 / 1
1 |
biogrid
No evidence text available
24711643
NTRK1 affects USP39
1 |
USP39 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NSUN2 affects USP39
1 |
USP39 binds NSUN2. 1 / 1
1 |
biogrid
No evidence text available
26344197
NOC3L affects USP39
1 |
USP39 binds NOC3L. 1 / 1
1 |
biogrid
No evidence text available
19615732
NCSTN affects USP39
1 |
NCSTN binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
NCL affects USP39
1 |
USP39 binds NCL. 1 / 1
1 |
biogrid
No evidence text available
27049334
NCAPD3 affects USP39
1 |
USP39 binds NCAPD3. 1 / 1
1 |
biogrid
No evidence text available
26344197
N-methyl-4-phenylpyridinium increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
26558463
MRM3 affects USP39
1 |
MRM3 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
MMS19 affects USP39
1 |
MMS19 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22678362
MLN7243 affects USP39
1 |
MLN7243 desumoylates USP39. 1 / 1
1 |
ctd
No evidence text available
31285264
MEPCE affects USP39
1 |
USP39 binds MEPCE. 1 / 1
1 |
biogrid
No evidence text available
17643375
LSM8 affects USP39
1 |
USP39 binds LSM8. 1 / 1
1 |
biogrid
No evidence text available
19615732
LINC00623 affects USP39
| 1
LINC00623 bound to NAT10 inhibits USP39. 1 / 1
| 1
reach
"Mechanistically, LINC00623 bound to N-acetyltransferase 10 (NAT10) and blocked its ubiquitination-dependent degradation by recruiting the deubiquitinase USP39."
35978332
LGALS9 affects USP39
1 |
USP39 binds LGALS9. 1 / 1
1 |
biogrid
No evidence text available
26344197
Histone affects USP39
| 1
Histone acetylates USP39. 1 / 1
| 1
reach
"The results of this study demonstrated that USP39 can be acetylated by the histone acetyltransferase MYST1, which is required for its proteasome mediated degradation by Von Hippel-Lindau protein."
32711345
HSPH1 affects USP39
1 |
HSPH1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
26344197
HSPA4 affects USP39
1 |
USP39 binds HSPA4. 1 / 1
1 |
biogrid
No evidence text available
26344197
HNRNPU affects USP39
1 |
USP39 binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
22939629
HNRNPC affects USP39
1 |
USP39 binds HNRNPC. 1 / 1
1 |
biogrid
No evidence text available
22939629
HIV1gp6 affects USP39
1 |
USP39 binds HIV1gp6. 1 / 1
1 |
biogrid
No evidence text available
22174317
HDAC_III affects USP39
| 1
HDAC_III deacetylates USP39 on lysine. 1 / 1
| 1
reach
"In HCC cells, USP39 interacts with and is deacetylated by the lysine deacetylase sirtuin 7 (SIRT7)."
32711345
GTF3C1 affects USP39
1 |
USP39 binds GTF3C1. 1 / 1
1 |
biogrid
No evidence text available
22939629
GAR1 affects USP39
1 |
GAR1 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
FOXA1 affects USP9X
| 1
USP10 binds USP7, USP9X, USP39, and FOXA1. 1 / 1
| 1
sparser
"To identify potential enzymes that could deubiquitinate FOXA1, we performed mass spectrometry analysis of FOXA1-associated proteins in LNCaP cells, which revealed multiple deubiquitinases, including USP7, USP39, USP10, and USP9X, that interact with FOXA1 (fig."
33827814
FN1 affects USP39
1 |
USP39 binds FN1. 1 / 1
1 |
biogrid
No evidence text available
19738201
FAM126A affects USP39
| 1
FAM126A inhibits USP39. 1 / 1
| 1
reach
"In addition, downregulation of ZEB1 was dramatically reversed in USP39 knockdown HCC cells (HepG2) treated with MG132 (an inhibitor of the ubiquitin–proteasome pathway) (Fig. 3E)."
33649471
EFTUD2 affects USP39
1 |
USP39 binds EFTUD2. 1 / 1
1 |
biogrid
No evidence text available
19615732
EAPP affects USP39
1 |
EAPP binds USP39. 1 / 1
1 |
biogrid
No evidence text available
28561026
USP39 binds DLGAP1 and Delta-actitoxin-Avd1a. 1 / 1
| 1
sparser
"Other non-coding RNAs, i.e.,: miR-34a, DLGAP1-AS1, USP39, and RNA5SP479, were highlighted by network analyses to have potential in the pathogenesis of UTUC."
35659483
DHX9 affects USP39
1 |
USP39 binds DHX9. 1 / 1
1 |
biogrid
No evidence text available
22939629
DHX38 affects USP39
1 |
DHX38 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
DDX24 affects USP39
1 |
DDX24 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
DDX23 affects USP39
1 |
DDX23 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
19615732
CUL7 affects USP39
1 |
USP39 binds CUL7. 1 / 1
1 |
biogrid
No evidence text available
24711643
CSNK1E affects USP39
1 |
USP39 binds CSNK1E. 1 / 1
1 |
biogrid
No evidence text available
26344197
COPRS affects USP39
1 |
USP39 binds COPRS. 1 / 1
1 |
biogrid
No evidence text available
19615732
CETN2 affects USP39
1 |
CETN2 binds USP39. 1 / 1
1 |
biogrid
No evidence text available
22939629
CDKN1B affects USP39
| 1
CDKN1A binds CDKN1B, USP39, and BAX. 1 / 1
| 1
sparser
"In addition, USP39 silencing was associated with the increased expressions of p21, p27, and Bax."
27456357
CDC5L affects USP39
1 |
CDC5L binds USP39. 1 / 1
1 |
biogrid
No evidence text available
20467437
CCDC8 affects USP39
1 |
USP39 binds CCDC8. 1 / 1
1 |
biogrid
No evidence text available
24711643
CAND1 affects USP39
1 |
USP39 binds CAND1. 1 / 1
1 |
biogrid
No evidence text available
21145461
BRCC36 affects USP39
| 1
STAT1 binds USP13, USP39, and BRCC36. 1 / 1
| 1
sparser
"For example, the three deubiquitinating enzymes BRCC36, USP13, and USP39 interact with STAT1 and decrease the K63-, K48- and K6-linked polyubiquitin chains of STAT1 respectively (110, 115, 118)."
34707613
BAX affects USP39
| 1
CDKN1A binds CDKN1B, USP39, and BAX. 1 / 1
| 1
sparser
"In addition, USP39 silencing was associated with the increased expressions of p21, p27, and Bax."
27456357
ARF1 affects USP39
1 |
USP39 binds ARF1. 1 / 1
1 |
biogrid
No evidence text available
26344197
APP affects USP39
1 |
USP39 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
APEH affects USP39
1 |
USP39 binds APEH. 1 / 1
1 |
biogrid
No evidence text available
26344197
ADARB1 affects USP39
1 |
USP39 binds ADARB1. 1 / 1
1 |
biogrid
No evidence text available
26344197
ADAM9 affects USP39
| 1
USP39 binds ADAM9. 1 / 1
| 1
sparser
"Furthermore, to determine whether USP39 could interact with ADAM9 and regulate the ubiquitination of ADAM9, we co‐transfected Myc‐tagged USP39, Flag‐tagged ADAM9 with or without HA tagged Ub plasmids into HEK293T cells; co‐immunoprecipitation experiments revealed that USP39 failed to interact with ADAM9 at the protein level (Fig.  xref ) and overexpressing USP39 had no effect on the polyubiquitination of ADAM9 (Fig. S9B)."
33811456
ACVR1 affects USP39
1 |
ACVR1 binds USP39. 1 / 1
1 |
hprd
No evidence text available
15761153
3-isobutyl-1-methyl-7H-xanthine increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
28628672
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
17942748
17alpha-ethynylestradiol increases the amount of USP39. 1 / 1
1 |
ctd
No evidence text available
17942748