IndraLab

Statements

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"However, the role of circRNA hsa_circ_0055440 (circ-USP39) in acute myocardial infarction regulation has not been studied yet."
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"Silencing of circ-USP39 alleviates hypoxia-induced cardiomyocyte injury via the miR-499b-5p/ACSL1 axis."
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"The head-to-tail splicing of circ-USP39 was verified by agarose gel electrophoresis."
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"This study aims to explore the effect of circ-USP39 on hypoxia-induced cardiomyocyte injury."
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"The interactions between miR-499b-5p and circ-USP39 (or acyl-CoA synthetase long-chain family member-1 (ACSL1) ) were verified by luciferase reporter assays."
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"After confirming the circular characteristics of circ-USP39, we further found that the circ-USP39 expression was upregulated in hypoxia-induced cardiomyocytes and the circ-USP39 knockdown facilitated the viability of hypoxia-induced AC16, while suppressing cardiomyocyte apoptosis and injury."
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"Importantly, circ-USP39 negatively regulated miR-499b-5p expression."
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"As a downstream target of miR-499b-5p, ACSL1 partially counteracted the protective effect of circ-USP39 depletion on cardiomyocyte injury."
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