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Syne homology proteins binds USP39. 1 / 1

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"In analogy to Klarsicht, Anc-1, and Syne homology proteins that accumulate at the ONM by binding to INM Sad1 and Unc-84 proteins (Sosa et al., 2013), we propose that Atg39 accumulates at the ONM by forming a translumenal bridge through direct or indirect interactions with the INM.We next asked whether the lumenal domain (with its transmembrane [TM] anchor) was sufficient to confer NE targeting and NE blebbing by making sequential N-terminal deletions."

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Syne homology proteins binds USP39. 1 / 1

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