IndraLab

Statements


E2F4 activates mutated USP39. 2 / 2
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"Consequently, e2f4 upregulation in usp39 mutants may contribute to increased proliferation of terminally differentiated pituitary cells leading to lineage expansion as seen in our BrdU studies (XREF_SUPPLEMENTARY)."

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"In addition, we performed quantitative RT-PCR analysis on the rb1 mRNA injected usp39 embryos and observed a 30% reduction of e2f4 expression compared to control uninjected usp39 mutants (XREF_SUPPLEMENTARY), indicating that e2f4 upregulation in usp39 mutant is secondary to Rb1 loss of function."