IndraLab

Statements

USP39 inhibits apoptotic process. 47 / 50
| 47
reach
"These results suggested USP39 knockdown could promote U2OS cell apoptosis."
28403900
reach
"Furthermore, we demonstrate that USP39 depletion promotes apoptosis induced by cisplatin, which is related with the induction of oxidative stress and DNA damage response."
34822033
reach
"Mechanism study showed that USP39 knockdown induced the arrest of cell cycle and apoptosis of leukemia cells."
30898977
reach
"Conversely, overexpression of USP39 attenuates apoptosis in RKO cells."
34822033
reach
"FCM assay showed that USP39 knockdown led to G2/M arrest and induced apoptosis in the HepG2 cells."
26081192
reach
"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
27456357
reach
"The inhibition of USP39 can induce G2/M phase arrest and promote apoptosis (Huang et al., 2016)."
36811009
reach
"Our loss-of-function experiments demonstrated that knockdown of the expression of USP39 repressed the proliferation of leukemia cells, induced cell cycle arrest, and cell apoptosis."
30898977
reach
"In addition, USP39 knockdown significantly induced apoptosis of leukemia cells."
30898977
reach
"Overall, the results suggest that USP39 facilitates cell proliferation and decreases cell apoptosis rate in cervical squamous cell carcinoma."
37957720
reach
"Knockdown of USP39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro [XREF_BIBR]."
30898977
reach
"Indeed, knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma [XREF_BIBR]."
30898977
reach
"Furthermore, USP39 silencing induced apoptosis of CAL27 cells via activations of Caspase 3 and PARP."
26835714
reach
"Silencing of USP39 induced cell apoptosis and cell cycle arrest at G2/M phase."
29328477
reach
"Meanwhile, knockdown of USP39 could arrest cell cycle at G2/M via cyclin dependent pathway and promoted apoptosis through PARP cleavage [XREF_BIBR - XREF_BIBR]."
28403900
reach
"Knockdown of USP39 can promote apoptosis and cell cycle arrest in HCC cells, and SP1 reverses these effects (26)."
37594129
reach
"Flow cytometric analysis showed that USP39 knockdown induced cell cycle arrest at G2/M phase and enhanced cell apoptosis in 95D cells."
27629785
reach
"Xu et al. reported that the knockdown of USP39 increased the levels of apoptosis-related proteins, such as caspase-3, caspase-8, caspase-9, and PARP, in RCCs, and inhibited the activation of ERK and AKT signaling pathways, resulting in an increase in the apoptosis rate of cancer cells [55]."
40347416
reach
"In order to further demonstrate the mechanisms of apoptosis induced by USP39 knockdown, the levels of cleaved cas3 and cleaved cas9 were increased in response to USP39 knockdown (XREF_FIG E, F)."
33255748
reach
"Silencing USP39 can inhibit the proliferation of melanoma cells in vitro and in vivo, induce G0/G1 arrest, and promote apoptosis."
30214236
reach
"Collectively, our data suggest that knocking down USP39 induces cell cycle arrest at S phase and G2/M phase, and results in apoptosis, and that the mechanism of apoptosis induced by USP39 knockdown may be related to DNA damage."
33255748
reach
"Moreover, USP39 silencing could promote U2OS cell apoptosis by PARP cleavage, which were reliable indicators of apoptosis."
28403900
reach
"In osteosarcoma cells, a decreased USP39 expression inhibited cell growth and induced apoptosis."
29805563
reach
"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis."
29805563
reach
"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
34987596
reach
"A mechanism study suggested that knockdown of USP39 induced apoptosis by downregulating the pre-mRNA splicing of FoxM1 [30]."
34987596
reach
"USP39 knockdown inhibits clonogenic capacity, induces cell cycle arrest, triggers apoptosis, and overcomes BTZ resistance."
39736693
reach
"Knockout of USP39 can inhibit tumor genesis, induce cell apoptosis, and inhibit lung adenocarcinoma cell metastasis [13]."
36046375
reach
"Consistent with the clinical correlation of USP39 in PC, the ectopic introduction of USP39 significantly enhanced proliferation of PC cells in vitro and in vivo , whereas knockdown of USP39 suppressed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28286270
reach
"It was found that USP39 silencing induced G2/M phase arrest and apoptosis, implying that the growth inhibition might be associated with increased cell cycle arrest and apoptosis."
26959883
reach
"Consistent with these findings, our data revealed that silencing of USP39 promotes PC cell apoptosis."
28286270
reach
"Our previous studies have established that USP39 knockdown induces cell cycle arrest at the G2/M phase in non-small cell lung cancer (NSCLC) and colorectal cancer cells, subsequently triggering apoptosis through activation of the p53 pathway [40, 41]."
40264098
reach
"In addition, the inhibition of USP39 induced G0/G1-phase arrest and apoptosis of the cells."
24126978
reach
"Furthermore, western blot analysis demonstrated that USP39 knockdown may have induced apoptosis through the upregulation of p53, p-p53, PARP and caspase-3 expression in SW1116 cells."
29556295
reach
"USP39 deficiency activates p53 pathway–induced apoptosis and metastasis in NSCLC [25]."
38987867
reach
"FCM indicated that USP39 knockdown led to G2/M arrest and induced apoptosis in SMMC-7721 cells."
28413501
reach
"For example, in multiple lung cancer cell lines, downregulation of USP39 confers cancer cells resistance to chemo- and radiotherapy and, conversely, silencing of USP39 in the case of pancreatic cancer induces apoptosis and suppresses tumor growth [111, 112]."
36732501
reach
"In addition, the results of Annexin V/7-AAD staining suggested the knockdown of USP39 could promote U2OS cell apoptosis through PARP cleavage."
28403900
reach
"Furthermore, inhibition of USP39 induced G0/G1-phase arrest and apoptosis in breast cancer cells."
28447728
reach
"Its level is negatively correlated with that of USP39, and knockdown of USP39 prolongs the half-life of p21 and induces apoptosis in colon cancer cell lines[41]."
38292842
reach
"Overexpression of USP39 reduces apoptosis in OC cells via down-regulation of caspase-3, resulting in resistance of OC cells into carboplatin chemotherapy."
32818654
reach
"We observed that the decrease of apoptosis by USP39 OE was partly diminished by shSP1 ( Fig. 7 C)."
34197957
reach
"USP39 knockdown promotes apoptosis."
29556295
reach
"This data demonstrated that USP39 silencing induced apoptosis in SW1116 cells."
29556295
reach
"Thus, it was demonstrated that the knockdown of USP39 in SW1116 cells induced apoptosis via altering the expression of apoptosis associated proteins."
29556295
reach
"These results suggested that knockdown of USP39 in SMMC-7721 cells could induce cell apoptosis via altering the expression of Bax, Caspase 9, Caspase 3 and PARP."
25889525
reach
"Further analysis confirmed that USP39 silencing significantly promoted the apoptosis of SW1116 cells."
29556295