IndraLab

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USP39 inhibits apoptotic process. 34 / 37
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"Collectively, our data suggest that knocking down USP39 induces cell cycle arrest at S phase and G2/M phase, and results in apoptosis, and that the mechanism of apoptosis induced by USP39 knockdown may be related to DNA damage."
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"Conversely, overexpression of USP39 attenuates apoptosis in RKO cells."
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"In order to further demonstrate the mechanisms of apoptosis induced by USP39 knockdown, the levels of cleaved cas3 and cleaved cas9 were increased in response to USP39 knockdown (XREF_FIG E, F)."
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"Besides, our experimental data revealed that knockdown of USP39 induced cell apoptosis through inhibition of AKT signaling pathway in PC cells."
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"Furthermore, USP39 silencing induced apoptosis of CAL27 cells via activations of Caspase 3 and PARP."
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"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
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"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis."
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"Flow cytometric analysis showed that USP39 knockdown induced cell cycle arrest at G2/M phase and enhanced cell apoptosis in 95D cells."
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"This data demonstrated that USP39 silencing induced apoptosis in SW1116 cells."
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"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
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"Indeed, knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma [XREF_BIBR]."
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"Moreover, USP39 silencing could promote U2OS cell apoptosis by PARP cleavage, which were reliable indicators of apoptosis."
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"FCM assay showed that USP39 knockdown led to G2/M arrest and induced apoptosis in the HepG2 cells."
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"In osteosarcoma cells, a decreased USP39 expression inhibited cell growth and induced apoptosis."
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"Silencing of USP39 induced cell apoptosis and cell cycle arrest at G2/M phase."
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"Further analysis confirmed that USP39 silencing significantly promoted the apoptosis of SW1116 cells."
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"In addition, the results of Annexin V/7-AAD staining suggested the knockdown of USP39 could promote U2OS cell apoptosis through PARP cleavage."
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"Meanwhile, knockdown of USP39 could arrest cell cycle at G2/M via cyclin dependent pathway and promoted apoptosis through PARP cleavage [XREF_BIBR - XREF_BIBR]."
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"Silencing USP39 can inhibit the proliferation of melanoma cells in vitro and in vivo, induce G0/G1 arrest, and promote apoptosis."
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"These results suggested USP39 knockdown could promote U2OS cell apoptosis."
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"Furthermore, we demonstrate that USP39 depletion promotes apoptosis induced by cisplatin, which is related with the induction of oxidative stress and DNA damage response."
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"Mechanism study showed that USP39 knockdown induced the arrest of cell cycle and apoptosis of leukemia cells."
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"These results suggested that knockdown of USP39 in SMMC-7721 cells could induce cell apoptosis via altering the expression of Bax, Caspase 9, Caspase 3 and PARP."
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"In addition, the inhibition of USP39 induced G0/G1-phase arrest and apoptosis of the cells."
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"USP39 knockdown promotes apoptosis."
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"Knockdown of USP39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro [XREF_BIBR]."
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"In addition, USP39 knockdown significantly induced apoptosis of leukemia cells."
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"A mechanism study suggested that knockdown of USP39 induced apoptosis by downregulating the pre-mRNA splicing of FoxM1 [30]."
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"Furthermore, western blot analysis demonstrated that USP39 knockdown may have induced apoptosis through the upregulation of p53, p-p53, PARP and caspase-3 expression in SW1116 cells."
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"Thus, it was demonstrated that the knockdown of USP39 in SW1116 cells induced apoptosis via altering the expression of apoptosis associated proteins."
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"It was found that USP39 silencing induced G2/M phase arrest and apoptosis, implying that the growth inhibition might be associated with increased cell cycle arrest and apoptosis."
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"Our loss-of-function experiments demonstrated that knockdown of the expression of USP39 repressed the proliferation of leukemia cells, induced cell cycle arrest, and cell apoptosis."
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"FCM indicated that USP39 knockdown led to G2/M arrest and induced apoptosis in SMMC-7721 cells."
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"Furthermore, inhibition of USP39 induced G0/G1-phase arrest and apoptosis in breast cancer cells."
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