IndraLab

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"Further studies are warranted to investigate the precise mechanism by which the USP39-mediated inhibition of ETS2’s nuclear localization occurs and subsequently leads to the transcriptional suppression of ETS2.USP39 has been traditionally considered an inactive DUB due to the substitution of the conserved cysteine residue at amino acid 234 in its USP domain with aspartate [30,31,32]."