IndraLab

Statements

USP39 binds CHEK2. 15 / 15
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"Additionally, endogenous immunoprecipitation further confirmed that USP39 binds to CHK2 ( Fig. 2 C and D)."
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"Hence, we next examined whether the interaction of USP39 and CHK2 was mediated by DNA damage."
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"In addition, the binding of USP39 and CHK2 didn't change upon Lambda protein phosphatase (λPP) treatment ( Fig. 2 G), suggesting that the interaction between USP39 and CHK2 is independence of DNA dama[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, our findings suggest that USP39 interacts with CHK2."
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"Since USP39-CHK2 axis regulates cell cycle checkpoint and apoptosis, we next examined the expression of Ki67 and cleaved caspase 3 in these cancer samples."
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"Furthermore, our data shown USP39-CHK2 axis playing an important role in regulation of apoptosis and cell cycle checkpoint induced by DNA damage."
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"Hence, we next examined whether USP39-CHK2 axis affects lung cancer cells response to chemotherapy and radiation."
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"Thus, we also examined the roles of USP39-CHK2 axis in chemo-radiation response."
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"Hence, our findings suggest that USP39-CHK2 axis may function as the potential biomarker for predicting chemo-radiation response in lung cancer."
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"Moreover, low level of USP39 is observed in lung cancers, which is correlated with the low level of CHK2 in these cancer samples, suggesting that USP39-CHK2 may play a role in treatment of lung cancer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To further demonstrate the mechanism by which USP39 regulates CHK2 protein level, we tested whether the USP39 binds to CHK2."
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