IndraLab

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SRSF6 binds USP39. 4 / 4
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"Moreover, the Co-IP assay also detected interaction between USP39 and SRSF6/HNRNPC in various mouse cell lines, suggesting this regulatory network is conserved between humans and mice (Fig. 7H)."
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"An additional GST-pulldown assay was conducted to investigate the interaction manner, and the findings indicated a direct interaction between HNRNPC and USP39, while SRSF6 interacted indirectly with USP39 (Fig. xref )."
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"Although a considerable fraction of AS events appear to be species-specific, the interaction between USP39 and SRSF6/HNRNPC is conserved between humans and mice."
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"This binding between SRSF6 and USP39 aids the recruitment of USP39 to the SRSF6-binding motif-enriched region."
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