IndraLab

Statements

USP39 binds E. 9 / 9
4 | 5
biogrid
No evidence text available
38158131
sparser
"Taken together, these results suggested that USP39 directly and specifically interacts with the E protein through the AR motif and performs its deubiquitination function using the iUSP motif."
38158131
biogrid
No evidence text available
38158131
biogrid
No evidence text available
38158131
biogrid
No evidence text available
38158131
sparser
"However, it was also found that USP39 interacts with the E protein, a highly conserved envelope protein of SARS-CoV-2, through its N-terminal arginine-rich modality, which reduces polyubiquitination of the E protein and protects it from degradation."
40990019
sparser
"Moreover, the interaction of USP39 and the E protein was readily detectable in reciprocal co-immunoprecipitation (co-IP) experiments ( Fig. 3 B and C)."
38158131
sparser
"A fluorescence resonance energy transfer (FRET) assay also showed the direct interaction of USP39 and the E protein, that is, bleaching of the fluorescence from E-yellow fluorescent protein (YFP) enha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38158131
sparser
"Similar to the above results, we also demonstrated that USP39 directly interacts with the substrate E protein via the AR motif, while the iUSP domain not required for E binding is required for E deubi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38158131