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MYC activates USP39. 4 / 4
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"Importantly, USP39 was transcriptionally activated by the oncogene protein c-MYC in ovarian cancer cells."
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"In contrast , inhibition of c-MYC by shRNA decreased USP39 expression ( Fig. 4A-B ) ."
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"The effect of c-MYC on USP39 expression was further investigated by performing a luciferase assay, and the result showed that forced expression of c-MYC increased luciferase activity of the USP39 promoter reporter containing the wild-type but not the mutant c-MYC binding site."
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"Furthermore, the loss of Usp39 dramatically delays Myc-driven B cell lymphomagenesis, highlighting Usp39 as a potential therapeutic target for B cell malignancies.To infer the stages in which Usp39 mi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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