IndraLab

Statements

Histone increases the amount of USP39. 5 / 5
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"Wei et al. observed significantly increased Kla in endometrial cancer tissues, where histone Kla enhances USP39 expression, driving the PI3K/AKT/HIF-1α pathway to promote malignancy 162."
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"Mechanically, histone lactylation stimulated USP39 expression to promote tumor progression."
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"Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1alpha signal pathway in endometrial carcinoma."
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"In addition, histone lactylation promotes malignant progression by promoting the expression of ubiquitin specific peptidase 39 (USP39) targeting the PI3K/AKT/HIF-1α signaling pathway in endometrial cancer (Wei et al., 2024)."
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"Mechanistically, histone lactylation promoted the expression of ubiquitin-specific peptidase 39 (USP39), which interacted with, stabilized, and de-ubiquitinated phosphoglycerate kinase 1 (PGK1), thereby activating the PI3K/AKT/HIF-1α signaling pathway."
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