IndraLab

Statements

USP39 increases the amount of GLI1. 6 / 6
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"USP39 undergoes LLPS in the nucleolus and promotes tumor progression by regulating GLI1 expression."
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"To investigate the regulation of GLI1 transcription by USP39, we performed GLI1 promoter luciferase reporter assay to assess the influence of USP39 on the transcription of GLI1."
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"USP39 knockdown suppresses GLI1 expression."
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"Furthermore, USP39 knockdown suppresses the expression of oncogenic transcription factor GLI1, which can also be reverted by USP39 complementation."
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"Moreover, knockdown of USP39 reduced oncogenic transcription effector GLI1 levels."
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"Consistently, the results showed that USP39 knockdown reduced GLI1 levels, which were reversed in USP39 rescue groups (Fig. 5G, H)."
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