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"An additional GST-pulldown assay was conducted to investigate the interaction manner, and the findings indicated a direct interaction between HNRNPC and USP39, while SRSF6 interacted indirectly with USP39 (Fig. xref )."

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"Supporting this, endogenous/ectopically overexpressed USP39 was coimmunoprecipitated with endogenous/ectopic overexpressed HNRNPC protein, suggesting that HNRNPC can interact and help recruit USP39 (Figs."

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"Moreover, the Co-IP assay also detected interaction between USP39 and SRSF6/HNRNPC in various mouse cell lines, suggesting this regulatory network is conserved between humans and mice (Fig. 7H)."

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"Although a considerable fraction of AS events appear to be species-specific, the interaction between USP39 and SRSF6/HNRNPC is conserved between humans and mice."