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USP39 inhibits epithelial to mesenchymal transition. 2 / 2

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"In addition, USP39 downregulation could inhibit the EMT phenotype in HCC cells (Fig. 3C)."

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"The zinc finger E-box binding homology cassette (ZEB1) is a key inducer of epithelial–mesenchymal transition (EMT), promoting cancer cell metastasis; USP39 inhibits the degradation of ZEB1 and promotes the development of EMT through deubiquitylation, further accelerating the invasion and metastasis of HCC cells [38]."

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IndraLab

Statements

USP39 inhibits epithelial to mesenchymal transition. 2 / 2

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