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USP39 increases the amount of CTLA4. 2 / 2

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"These results suggest that lactate induces Foxp3 expression and then promotes USP39-dependent CTLA-4 expression in Treg cells."

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"This enhanced Treg cell function is partially mediated by lactate-dependent ubiquitin-specific peptidase 39 (USP39), a component of the RNA splicing machinery, to augment cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression in a FOXP3-dependent manner and, thus, to prevent cytotoxic T cell function [128]."

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USP39 increases the amount of CTLA4. 2 / 2

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