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USP39 activates cell population proliferation. 51 / 56
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"It was found in our previous study that USP39 knockdown could inhibit the abnormal proliferation of prostate cancer cells by inhibiting the splicing maturation and transcriptional prolongation of EGFR mRNA [16]."
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"Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro."
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"USP39 knockdown inhibited the proliferation and colony formation of A549 and HCC827 cells and decreased tumorigenic potential in nude mice."
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"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
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"The inducible shRNA mediated downregulation of USP39 expression markedly reduced the proliferation and colony forming ability of MDA-MB-231 cells, while overexpression of USP39 by the inducible system did not promote cancer cell proliferation."
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"In addition, overexpression of HMGA2 rescued the inhibition of proliferation, invasion and xenograft growth induced by silencing USP39."
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"Simultaneously, USP39 knockdown inhibited the proliferation of HCC cells transfected with shTRIM26."
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"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
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"In conclusion, the present study has revealed that USP39 silencing suppressed CRC cell proliferation via activating the caspase cascade and upregulating the expression of p53."
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"Furthermore, these results suggested that suppression of USP39 could inhibit cell proliferation and colony formation of HCC cells."
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"To elucidate the molecular mechanisms by which USP39 knockdown inhibits cell proliferation, we next investigated its effect on cell cycle distribution and cell apoptosis."
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"Suppression of USP39 expression significantly decreased the proliferation and colony forming ability of MGC80-3 cells as indicated by an MTT and a clonogenic assay, respectively."
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"USP39 promotes proliferation and invasion in vitro and tumor growth in vivo."
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"Notably, the deacetylation of USP39 by SIRT7 promotes its stability and thereby accelerates HCC cell proliferation and tumorigenesis invitro and invivo."
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"Subsequent functional experiments revealed that USP39 promoted the proliferation and invasion of ovarian cancer cells in vitro and tumor growth in vivo."
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"Wen et al. [33] reported that overexpression of USP39 could promote the malignant proliferation of prostate cancer cells."
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"Taken together, our findings implicate that USP39 promotes the development of human leukemia by regulating cell cycle, survival, and proliferation of the cells."
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"Knocking Down USP39 Inhibits the G2 / M Cell Cycle Transition and Induces Apoptosis To elucidate the molecular mechanisms by which USP39 knockdown inhibits cell proliferation , we next investigated its effect on cell cycle distribution and cell apoptosis ."
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"Silencing USP39 can inhibit the proliferation of melanoma cells in vitro and in vivo, induce G0/G1 arrest, and promote apoptosis."
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"Wen et al demonstrated that the overexpression of USP39 promoted the proliferation of prostate cancer cells, which is in accord with a study by Wang et al in breast cancer cells."
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"The results showed that USP39 knockdown markedly repressed the proliferation rate of HL-60 and Jurkat cells since day 3 (XREF_FIG C, D)."
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"Herein, we demonstrate for the first time that the molecular mechanisms of USP39-mediated cell proliferation and metastasis in HCC might be involved in the regulation of the ZEB1-dependent EMT axis."
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"Lentivirus mediated knockdown of USP39 repressed the proliferation and colony formation of human leukemia cell lines HL-60 and Jurkat cells."
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"In addition , our results show USP39 promotes cell proliferation by SP1-depenet manner in vivo and vitro ."
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"miR-133a, directly targeted USP39, suppresses cell proliferation and predicts prognosis of gastric cancer."
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"As shown in Fig. 3, the MTT growth curve indicated that the cell proliferation was significantly inhibited by USP39 silencing compared with the control group (Fig. 3F, G)."
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"Wen et al. demonstrated that the overexpression of USP39 could enhance the proliferation of prostate cancer cells, suggesting that USP39 may also play a role in prostate cancer development [XREF_BIBR]."
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"USP39 mediates p21 dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis."
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"To test the mechanism by which USP39 modulating cell proliferation, the flow cytometry assay was used to determine the cell cycle of TT cells."
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"Furthermore, USP39 knockdown in VSMCs significantly reduced proliferation compared with cells transfected with control siRNA (P = 0.0238; XREF_FIG)."
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"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
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"A sumosylated USP39 has been shown to promote the proliferation of PC-3 and LNcap cells [XREF_BIBR]."
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"Moreover, recent studies indicated that knocking down USP39 promoted cell proliferation in different types of cancers [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Mutation of these SUMO modification sites of USP39 further promoted the proliferation enhancing effect of USP39 on prostate cancer cells."
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"Our data support the evidence that USP39 acts a novel deubiquitinating enzyme of Cyclin B1 and promoted tumor cell proliferation at least in part through Cyclin B1 stabilization, represents a promising therapeutic strategy for tumor patients."
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"Our previous studies have shown that overexpressed USP39 can promote the proliferation and migration of human ovarian cancer by targeting EMT [15]."
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
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"USP39 promotes HCC proliferation and migration in vitro."
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"MTT assay showed that USP39 knockdown inhibited cell proliferation."
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"The depletion of USP39 could inhibit the proliferation and metastasis of HCC cells [11]."
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"In conclusion, our studies indicated that suppression of USP39 through recombinant lentivirus taking shUSP39 inhibited cell proliferation and colony formation of HCC cells along with cell cycle arrest at G 2 / M phase."
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"In addition, our results show USP39 promotes cell proliferation by SP1-depenet manner in vivo and vitro."
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"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
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"Indeed, silencing USP39 expression markedly inhibited the proliferation and metastasis of HCC cells in vitro and in vivo experiments, indicating the potential carcinogenic effect of USP39 in HCC development."
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"USP39 overexpression promotes cell proliferation and predicts poor prognosis, which is consistent with present research."
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"Thus, depletion of USP39 could inhibit the proliferation and metastasis of HCC cells."
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"This indicates that knockdown of USP39 could strongly decrease the proliferation of TT cells."
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"Taken together, these results suggest that knockdown of USP39 could inhibit TT cell proliferation by inducing G2/M phase cell cycle arrest."
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"USP39 increases proliferation and invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice."
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"Furthermore, high USP39 expression was observed in PC cell lines and ectopic expression of USP39 significantly enhanced invitro cell proliferation and promoted invivo tumor growth, whereas silencing USP39 suppressed growth of PC cells."
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"Conversely, USP39 knockdown inhibited proliferation in tumor size and weight of SK-hep-1 cells transfected with shTRIM26."
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