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USP39 activates cell population proliferation. 90 / 95
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"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
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"Knockdown of USP39 expression in HCC can significantly inhibit cell proliferation, resulting in cell cycle arrest at the G2/M phase [62]."
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"The de-acetylation of USP39 by SIRT7 can promote its stability and thereby accelerate HCC cell proliferation and tumorigenesis."
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"In human liver cancer cells, USP39 promoted tumor proliferation in a spliceosome-dependent manner."
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"In summary, USP39 significantly promotes the proliferation of HCC cells and enhances their capacity for invasion and metastasis through mechanisms that include the regulation of the Wnt/β-catenin signaling pathway, metabolic reprogramming, and EMT."
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"Unlike wild-type USP39, which rescued the inhibitory effect of USP39 deficiency on cell proliferation and cell cycle progression, the C139A mutant could not reverse the suppressive effects (Figs."
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"Zhao et al. further indicated that USP39 promoted the proliferation of ESCC cells by enhancing the splicing and maturation of Rictor mRNA, a component of the mTOR complex, and regulating the mTORC2 signaling pathway [50]."
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"miR-133a, directly targeted USP39, suppresses cell proliferation and predicts prognosis of gastric cancer."
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"The depletion of USP39 could inhibit the proliferation and metastasis of HCC cells [11]."
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"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
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"For example, USP39 can promote the proliferation and growth of cancer cells in colon cancer cells, pancreatic cancer cells, and gastric cancer cells [9–11]."
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"Thus, depletion of USP39 could inhibit the proliferation and metastasis of HCC cells."
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"USP39 overexpression promotes cell proliferation and predicts poor prognosis, which is consistent with present research."
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"Furthermore, USP39 knockdown in VSMCs significantly reduced proliferation compared with cells transfected with control siRNA (P = 0.0238; XREF_FIG)."
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"In addition , our results show USP39 promotes cell proliferation by SP1-depenet manner in vivo and vitro ."
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"A sumosylated USP39 has been shown to promote the proliferation of PC-3 and LNcap cells [XREF_BIBR]."
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"USP39 promotes proliferation and invasion in vitro and tumor growth in vivo."
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"USP39 increases proliferation and invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice."
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"In addition, overexpression of HMGA2 rescued the inhibition of proliferation, invasion and xenograft growth induced by silencing USP39."
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"Subsequent functional experiments revealed that USP39 promoted the proliferation and invasion of ovarian cancer cells in vitro and tumor growth in vivo."
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"Silencing USP39 can inhibit the proliferation of melanoma cells in vitro and in vivo, induce G0/G1 arrest, and promote apoptosis."
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"Mutation of these SUMO modification sites of USP39 further promoted the proliferation enhancing effect of USP39 on prostate cancer cells."
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"For example, USP39 promotes cell cycle, and proliferation, resulting in the development of leukemia [6] ."
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"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
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"Here, we confirmed that USP39 was highly expressed in NPC tissues by IHC, and over-expressed USP39 promoted NPC cell proliferation, while silencing USP39 suppressed it."
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"The deacetylation of USP39 by SIRT7 promotes the stability and thereby accelerates cell proliferation and tumorigenesis of HCC [10] ."
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"It was found in our previous study that USP39 knockdown could inhibit the abnormal proliferation of prostate cancer cells by inhibiting the splicing maturation and transcriptional prolongation of EGFR mRNA [16]."
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"Our data suggested that USP39 activation promotes HCC cell proliferation, and inhibits cell apoptosis.DUBs have recently been identified for their contributions to many types of cancers."
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"As shown in Fig. 3, the MTT growth curve indicated that the cell proliferation was significantly inhibited by USP39 silencing compared with the control group (Fig. 3F, G)."
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"And knocking-down of USP39 and co-expression of SP1 significantly induced cell growth and proliferation compared with knocking-down of USP39 only."
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"Wen et al. [33] reported that overexpression of USP39 could promote the malignant proliferation of prostate cancer cells."
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"Suppression of USP39 expression significantly decreased the proliferation and colony forming ability of MGC80-3 cells as indicated by an MTT and a clonogenic assay, respectively."
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"USP39 promotes HCC cell proliferation and migration by deubiquitinating β-catenin, activating WNT/β-catenin signaling pathway [12]."
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"Specifically, USP39 promotes breast cancer cell proliferation and tumor growth by deubiquitinating and stabilizing the transcription factor FOXM1 [31]."
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"Mechanistically, USP39 stabilized MRPL35 expression by deubiquitination and then promoted NSCLC cell proliferation, invasion, and glutamine metabolism."
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"Finally, Gan and Coll showed that deletion of USP39 in U2OS cells reduces cell proliferation and blocks their ability to form colonies."
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"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin beta-catenin, a key molecular of Wnt/beta-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
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"Moreover, USP39 depletion inhibits HCC cell proliferation and metastasis by promoting ZEB1 degradation."
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"Additionally, USP39 silencing was demonstrated to suppress cell proliferation potential and promote cell apoptosis in cervical squamous cell carcinoma in vitro.USP39 has been reported to positively regulate FOXM1 expression in hepatocellular carcinoma [27]."
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"It has also been reported that the expression of USP39 is increased in nasopharyngeal carcinoma tissues, the overexpression of USP39 can promote the proliferation of nasopharyngeal carcinoma cells, and the expression of USP39 is regulated by the LINC00520/miR-26b-3p axis."
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"Our previous studies have shown that overexpressed USP39 can promote the proliferation and migration of human ovarian cancer by targeting EMT [15]."
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"Moreover, we transfected Flag‐MRPL35 and si‐NC or si‐USP39 into 293 T cells and found that USP39 silencing enhanced MRPL35 ubiquitination (Figure 3H).3.4 USP39 Knockdown Suppresses NSCLC Cell Proliferation, Invasion, and Glutamine Metabolism and Induces Cell Apoptosis by MRPL35."
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"USP39 knockdown inhibited the proliferation and colony formation of A549 and HCC827 cells and decreased tumorigenic potential in nude mice."
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"USP39 promotes HCC proliferation and migration in vitro."
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"Moreover, recent studies indicated that knocking down USP39 promoted cell proliferation in different types of cancers [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"To elucidate the molecular mechanisms by which USP39 knockdown inhibits cell proliferation, we next investigated its effect on cell cycle distribution and cell apoptosis."
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"For instance, USP39 is overexpressed in lung cancer and promotes tumor cell proliferation [8] ."
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"As shown in Fig. 2 B–C, we found that USP39-overexpressing cells showed a significantly higher in vitro proliferation rate than vector-transfected cells and knockdown of USP39 obviously suppressed the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, downregulation of USP39 by the specific USP39 siRNA was also inhibited the proliferation of PANC-1 cells ( Fig. 2 D)."
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"On the other, USP39 promotes the proliferation and invasion of HCC cells by inhibiting splicing of TRIM26, thus affecting the ubiquitin of β-catenin induced by TRIM26."
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"Simultaneously, USP39 knockdown inhibited the proliferation of HCC cells transfected with shTRIM26."
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"Ubiquitin-specific peptidase 39 can promote HCC proliferation by participating in the deubiquitination of SP1[75]."
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"USP39 increases proliferation and migration of HCC cells through the Wnt/beta-catenin pathway."
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"Consistent with the clinical correlation of USP39 in PC, the ectopic introduction of USP39 significantly enhanced proliferation of PC cells in vitro and in vivo , whereas knockdown of USP39 suppressed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"MTT results indicated that knockdown of USP39 reduced the proliferation of HCC cells compared with the control group, while replenishment of USP39 restored the proliferation of HCC cells."
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"Conversely, USP39 knockdown inhibited proliferation in tumor size and weight of SK-hep-1 cells transfected with shTRIM26."
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"Here, our in vitro and in vivo experimental data showed that overexpression of USP39 significantly enhanced PC cells proliferation, whereas knockdown of USP39 suppressed PC cells proliferation."
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"Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro."
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"These data demonstrated that USP39 increases the proliferation and migration of HCC cells through the Wnt/β-catenin pathway."
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"USP39 mediates p21 dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis."
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"Indeed, silencing USP39 expression markedly inhibited the proliferation and metastasis of HCC cells in vitro and in vivo experiments, indicating the potential carcinogenic effect of USP39 in HCC development."
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"In vitro experimental validation confirmed that USP39 knockdown inhibited migration and proliferation of pancreatic cancer cells while inducing apoptosis."
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"Wen et al. demonstrated that the overexpression of USP39 could enhance the proliferation of prostate cancer cells, suggesting that USP39 may also play a role in prostate cancer development [XREF_BIBR]."
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"Herein, we demonstrate for the first time that the molecular mechanisms of USP39-mediated cell proliferation and metastasis in HCC might be involved in the regulation of the ZEB1-dependent EMT axis."
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"Depletion of USP39 inhibits cell proliferation and migration and induces cell death in human pancreatic cancer cells."
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"Consistent with this finding, EdU incorporation assays further demonstrated that USP39 knockdown markedly reduced DNA synthesis and cell proliferation (Fig. 3D)."
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"A similar molecular signature was observed in PAAD, and our experimental findings demonstrated that elevated USP39 expression significantly enhanced cell proliferation and wound healing capacity in PAAD."
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"This indicates that knockdown of USP39 could strongly decrease the proliferation of TT cells."
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"To test the mechanism by which USP39 modulating cell proliferation, the flow cytometry assay was used to determine the cell cycle of TT cells."
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"Our results showed that USP39 knockdown reduced the proliferation and migration of pancreatic cancer cells and increased cell death in vitro, suggesting a potential role of USP39 in pancreatic cancer cell growth and survival."
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"Taken together, these results suggest that knockdown of USP39 could inhibit TT cell proliferation by inducing G2/M phase cell cycle arrest."
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"Initially, Pan et al. indicated USP39 silencing could cause proliferation inhibition and G2/M phase retardation [48]."
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"Lentivirus mediated knockdown of USP39 repressed the proliferation and colony formation of human leukemia cell lines HL-60 and Jurkat cells."
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"Taken together, our findings implicate that USP39 promotes the development of human leukemia by regulating cell cycle, survival, and proliferation of the cells."
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"The results showed that USP39 knockdown markedly repressed the proliferation rate of HL-60 and Jurkat cells since day 3 (XREF_FIG C, D)."
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"USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance."
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"The significance of USP39/SMC4 in promoting the viability and proliferation of HepG2 cells."
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"The inducible shRNA mediated downregulation of USP39 expression markedly reduced the proliferation and colony forming ability of MDA-MB-231 cells, while overexpression of USP39 by the inducible system did not promote cancer cell proliferation."
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"Knocking Down USP39 Inhibits the G2 / M Cell Cycle Transition and Induces Apoptosis To elucidate the molecular mechanisms by which USP39 knockdown inhibits cell proliferation , we next investigated its effect on cell cycle distribution and cell apoptosis ."
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"MTT assay showed that USP39 knockdown inhibited cell proliferation."
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"Using CCK8, EdU, and colony formation assays, as well as in vivo trials, USP39 was shown to promote EC proliferation and migration."
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"Wen et al demonstrated that the overexpression of USP39 promoted the proliferation of prostate cancer cells, which is in accord with a study by Wang et al in breast cancer cells."
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"Furthermore, these results suggested that suppression of USP39 could inhibit cell proliferation and colony formation of HCC cells."
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"We found that USP39 could upregulate Cyclin B1 protein stability to promote G2/M cell cycle transition and glioma cell proliferation, as well as tumor growth in vivo."
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"USP39 promotes glioma cells proliferation via Cyclin B1."
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"As shown in Fig. 4a, knockdown of USP39 significantly inhibited the U251 cells proliferation at 48 h, 72 h and 96 h (p < 0.001) and inhibited the growth of U87 cells at 72 h and 96 h (p < 0.001)."
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"In line with these results, USP39 knockdown also decreased the proliferation of MGC-803 and HGC-27 cells."
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"However, the mechanisms by which USP39 depletion inhibits GC proliferation require further investigation."
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"In conclusion, our studies indicated that suppression of USP39 through recombinant lentivirus taking shUSP39 inhibited cell proliferation and colony formation of HCC cells along with cell cycle arrest at G 2 / M phase."
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"In conclusion, the present study has revealed that USP39 silencing suppressed CRC cell proliferation via activating the caspase cascade and upregulating the expression of p53."
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