IndraLab

Statements

USP39 activates CCNB1. 4 / 4
| 4
reach
"USP39 mediates p21 dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis."
33634905
reach
"Taken together, these results suggest that USP39 knockdown promotes Cyclin B1 protein degradation in a proteasome-dependent manner."
37302347
reach
"We found that USP39 could upregulate Cyclin B1 protein stability to promote G2/M cell cycle transition and glioma cell proliferation, as well as tumor growth in vivo."
37302347
reach
"A cycloheximide (CHX) chase assay in U251 and U87 cells showed that knockdown of USP39 decreased the half-life of Cyclin B1 (Fig. 1j), and upregulation of USP39 increased the half-life of Cyclin B1 (Fig. 1k)."
37302347