IndraLab

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USP39 activates CCNB1. 4 / 4
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"Taken together, these results suggest that USP39 knockdown promotes Cyclin B1 protein degradation in a proteasome-dependent manner."
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"We found that USP39 could upregulate Cyclin B1 protein stability to promote G2/M cell cycle transition and glioma cell proliferation, as well as tumor growth in vivo."
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"USP39 mediates p21 dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis."
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"A cycloheximide (CHX) chase assay in U251 and U87 cells showed that knockdown of USP39 decreased the half-life of Cyclin B1 (Fig. 1j), and upregulation of USP39 increased the half-life of Cyclin B1 (Fig. 1k)."
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