IndraLab

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USP39 inhibits TRIM26. 5 / 5
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"Using two pairs of primers, one for alternative splicing and the other for constitutive splicing of the TRIM26 mRNA, we confirmed that knockdown of USP39 increased alternative splicing of TRIM26 mRNA whereas constitutive splicing did not (Fig. 5F)."
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"Moreover, overexpression of USP39 reduced the alternative splicing of TRIM26 mRNA with no effect on the constitutive splicing (Fig.5G)."
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"We confirmed that USP39 deletion increased the alternate splicing transcript of TRIM26 without significant changes in its constitutive splicing."
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"USP39 suppressed the shearing and maturation of TRIM26 precursor mRNA, as demonstrated by immunoprecipitation experiments indicating a direct interaction between the two."
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"We hypothesized that USP39 antagonizes TRIM26 in targeting ZEB1 for ubiquitin-dependent proteasomal degradation, to regulate the proliferation and migration of HCC cells."
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