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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP39 leads to the ubiquitination of ZEB1. 2 / 2

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"Since ubiquitination and stability play important roles in ZEB1 regulation, hypothetically, USP39 with the function of deubiquitination could promote HCC progression through regulating the level of ZEB1 ubiquitination.The tripartite motif (TRIM) family proteins possess one or two B-boxes along with its domain structure, and a more diverse domain at the C terminus [20, 21], which are considered key regulators of protein degradation through ubiquitylation."

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"Clearly, the downregulation of USP39 greatly promoted ZEB1 ubiquitination in HepG2 and SK-hep-1 cells (Fig. 3F)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...