IndraLab

Statements

USP39 activates RB1. 3 / 3
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"Our studies reveal a novel role of usp39 mediated mRNA splicing of rb1 in pituitary cell growth control, which is critical for maintaining embryonic pituitary homeostasis."
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"It showed that the down-regulation of USP39 gene can cause rb1 mRNA splicing abnormalities, which then leaded to downstream target genes e2f4 up-regulated in zebrafish."
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"We then performed an rb1 mRNA overexpression experiment in usp39 mutants and observed partial rescue of the adenohypophysis phenotype (XREF_FIG, mutant N = 34, ~ 50% showed rescue), validating the importance of usp39 mediated rb1 mRNA splicing in controlling pituitary lineage expansion during development."
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